PMID- 35168545
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220219
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Feb 15
TI  - Human herpesvirus 6 infection as a trigger of multiple sclerosis: an update of 
      recent literature.
PG  - 57
LID - 10.1186/s12883-022-02568-7 [doi]
LID - 57
AB  - BACKGROUND: This is an update on the existing evidence regarding a relationship 
      between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) in 
      order to contribute on the attempt to define the nature and strength of that 
      relationship. RESULTS: Study quality was assessed using the criteria proposed by 
      Moore and Wolfson and by the classification criteria used by the Canadian Task 
      Force on the Periodic Health Examination. Studies were categorized both by 
      experimental technique and by quality (high [A], intermediate [B], and low [C]) 
      as determined by the Moore and Wolfson criteria. Overall, 27 (90%) of 30 studies, 
      18 (86%) of which were classified as A quality, reached a statistically 
      significant result. According to the Canadian Task Force classification, all 
      studies were categorized as evidence of qualityII-1. Limitations of the available 
      experimental techniques and perspectives for future research are discussed. 
      CONCLUSIONS: The current review continues to emphasize the need for further, 
      objective, evidence-based examination of the relationship between HHV-6 infection 
      and multiple sclerosis.
CI  - (c) 2022. The Author(s).
FAU - Voumvourakis, K I
AU  - Voumvourakis KI
AD  - 2nd Department of Neurology, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece. cvoumvou@outlook.com.
FAU - Fragkou, P C
AU  - Fragkou PC
AD  - 4th Department of Internal Medicine, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Kitsos, D K
AU  - Kitsos DK
AD  - 2nd Department of Neurology, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Foska, K
AU  - Foska K
AD  - 2nd Department of Neurology, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Chondrogianni, M
AU  - Chondrogianni M
AD  - 2nd Department of Neurology, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
FAU - Tsiodras, S
AU  - Tsiodras S
AD  - 4th Department of Internal Medicine, Attikon University Hospital, National and 
      Kapodistrian University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220215
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral
MH  - *Herpesvirus 6, Human/genetics
MH  - Humans
MH  - *Multiple Sclerosis/epidemiology
MH  - *Roseolovirus Infections/complications/epidemiology
PMC - PMC8845292
OTO - NOTNLM
OT  - CSF
OT  - Cerebrospinal fluid
OT  - Demyelination
OT  - Diagnosis
OT  - Etiology
OT  - HHV-6
OT  - Human herpes virus 6,IgG antibodies
OT  - IgM antibodies
OT  - Multiple sclerosis
OT  - Pathogenesis,pcr
OT  - Polymerase Chain Reaction
OT  - Polymorphisms
OT  - Serology
COIS- Not applicable
EDAT- 2022/02/17 06:00
MHDA- 2022/02/19 06:00
PMCR- 2022/02/15
CRDT- 2022/02/16 05:34
PHST- 2021/02/23 00:00 [received]
PHST- 2021/10/22 00:00 [accepted]
PHST- 2022/02/16 05:34 [entrez]
PHST- 2022/02/17 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2022/02/15 00:00 [pmc-release]
AID - 10.1186/s12883-022-02568-7 [pii]
AID - 2568 [pii]
AID - 10.1186/s12883-022-02568-7 [doi]
PST - epublish
SO  - BMC Neurol. 2022 Feb 15;22(1):57. doi: 10.1186/s12883-022-02568-7.