PMID- 35171332
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220728
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 260
IP  - 8
DP  - 2022 Aug
TI  - Screening of telangiectatic capillaries in chronic macular edema based on 
      multimodal imaging: a study of 101 eyes. LyoMAC1 study.
PG  - 2501-2508
LID - 10.1007/s00417-022-05592-y [doi]
AB  - PURPOSE: To estimate the prevalence of telangiectatic capillaries (TCs) in 
      patients followed for chronic macular edema (CME) (diabetic ME [DME] and ME 
      associated with retinal vein occlusion [RVO]). METHODS: Real-life, prospective, 
      bi-centric cohort study including all consecutive patients followed for a 
      clinically significant CME secondary to diabetic retinopathy or RVO. Inclusion 
      criteria were patients treated with intravitreal injection for their ME for at 
      least 12 months who had to undergo follow-up angiography. Multimodal imaging with 
      color retinophotography, spectral-domain optical coherence tomography (SD-OCT), 
      OCT angiography, and en face OCT was performed in all patients. RESULTS: A total 
      of 101 eyes of 71 patients were included between November 2019 and June 2020. Of 
      the 101 eyes analyzed, indocyanine green angiography found at least one TC in 67 
      eyes (66.3%). No significant differences were found between the groups with and 
      without TC except for the distribution of DME and RVO (p < 0.008). In 83.6% of 
      eyes with TCs, TCs contributed to the formation of the ME. SD-OCT sensitivity for 
      TC detection was 94%. CONCLUSION: In our study, the estimated prevalence of TCs 
      in CME (DME and ME associated with RVO) was 66.3%, i.e., two-thirds of patients. 
      SD-OCT was an excellent screening examination with a sensitivity of 94%.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Chaperon, Mayeul
AU  - Chaperon M
AD  - Ophthalmology Department, Hopital d'Instruction Des Armees Desgenettes, 108, 
      Boulevard Pinel, 69003, Lyon, France.
FAU - Kodjikian, Laurent
AU  - Kodjikian L
AD  - Ophthalmology Department, Hopital de La Croix Rousse, Hospices Civils de Lyon, 
      Lyon, France.
FAU - Agard, Emilie
AU  - Agard E
AD  - Ophthalmology Department, Hopital d'Instruction Des Armees Desgenettes, 108, 
      Boulevard Pinel, 69003, Lyon, France.
FAU - Mathis, Thibaud
AU  - Mathis T
AD  - Ophthalmology Department, Hopital de La Croix Rousse, Hospices Civils de Lyon, 
      Lyon, France.
FAU - Billant, Jeremy
AU  - Billant J
AD  - Ophthalmology Department, Hopital d'Instruction Des Armees Desgenettes, 108, 
      Boulevard Pinel, 69003, Lyon, France.
FAU - El-Chehab, Hussam
AU  - El-Chehab H
AD  - Ophthalmology Department, Hopital d'Instruction Des Armees Desgenettes, 108, 
      Boulevard Pinel, 69003, Lyon, France.
AD  - French Military Health Service Academy, Val de Grace, Paris, France.
FAU - Pradat, Pierre
AU  - Pradat P
AD  - Clinical Research Center, Hopital de La Croix Rousse, Hospices Civils de Lyon, 
      Lyon, France.
FAU - Dot, Corinne
AU  - Dot C
AD  - Ophthalmology Department, Hopital d'Instruction Des Armees Desgenettes, 108, 
      Boulevard Pinel, 69003, Lyon, France. corinnedot.pro@hotmail.fr.
AD  - French Military Health Service Academy, Val de Grace, Paris, France. 
      corinnedot.pro@hotmail.fr.
LA  - eng
PT  - Journal Article
DEP - 20220216
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Capillaries
MH  - Cohort Studies
MH  - *Diabetic Retinopathy/complications
MH  - Fluorescein Angiography/methods
MH  - Humans
MH  - *Macular Edema/complications/etiology
MH  - Prospective Studies
MH  - *Retinal Vein Occlusion/diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity
OTO - NOTNLM
OT  - Capillary macroaneurysms
OT  - Chronic macular edema
OT  - Diabetic macular edema
OT  - Retinal vein occlusion
OT  - Telangiectatic capillaries
EDAT- 2022/02/17 06:00
MHDA- 2022/07/29 06:00
CRDT- 2022/02/16 12:16
PHST- 2021/10/25 00:00 [received]
PHST- 2022/02/10 00:00 [accepted]
PHST- 2022/01/12 00:00 [revised]
PHST- 2022/02/17 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/02/16 12:16 [entrez]
AID - 10.1007/s00417-022-05592-y [pii]
AID - 10.1007/s00417-022-05592-y [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2022 Aug;260(8):2501-2508. doi: 
      10.1007/s00417-022-05592-y. Epub 2022 Feb 16.