PMID- 35171542
OWN - NLM
STAT- MEDLINE
DCOM- 20220218
LR  - 20220531
IS  - 1110-4902 (Print)
VI  - 29
IP  - 1
DP  - 2022 Jan
TI  - Toll-Like Receptor-4 Gene (Asp299Gly) polymorphism in allergic conjunctivitis.
PG  - 1-12
AB  - Allergic conjunctivitis (AC) is an allergic reaction that causes inflammation of 
      the conjunctiva. Toll-like receptors (TLRs) are essential innate immune receptors 
      that contribute to developing various allergic diseases. This case-control study 
      aims to determine the correlation between TLR-4 gene (Asp299Gly) polymorphism and 
      AC incidence and severity. The study included 70 AC patients and 70 non-allergic 
      controls. All included subjects were subjected to a skin prick test, total 
      immunoglobulin E (IgE) measurement, and TLR-4 gene (Asp299Gly) polymorphism 
      detection by PCR restriction fragment length polymorphism (PCR-RFLP) technique. 
      AC patients had significantly higher total IgE levels than controls (P </= 0.001). 
      The frequency of the wild-type AA and heterozygous AG genotype were significantly 
      lower in AC patients compared to controls (60 % vs. 80 % and 8.6% vs. 12.9 %, 
      respectively). In contrast, the homozygous mutant GG genotype was significantly 
      more prevalent among AC patients than controls (31.4 % vs. 7.1 %). Furthermore, 
      the wild AA genotype was strongly associated with mild disease (68.2%); 
      nonetheless, the homozygous mutant GG genotype was linked to severe disease 
      (53.8%). The heterozygous AG genotype was only found in moderate AC patients 
      (17.1%). AC patients with the mutant G allele may be more likely to have a severe 
      course of AC.
CI  - Copyright(c) by the Egyptian Association of Immunologists.
FAU - Baioumy, Shereen A
AU  - Baioumy SA
AD  - Department of Microbiology & Immunology,Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - Taha, Sara I
AU  - Taha SI
AD  - Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, 
      Cairo, Egypt.
FAU - Sallam, Dina E
AU  - Sallam DE
AD  - Department of Pediatric & Pediatric Nephrology, Faculty of Medicine, Ain Shams 
      University, Cairo, Egypt.
FAU - Alashry, Ahmed I A
AU  - Alashry AIA
AD  - Department of Ophthalmology, Military Medical Academy, Cairo, Egypt.
FAU - Fouad, Shaimaa H
AU  - Fouad SH
AD  - Department of Internal Medicine & Allergy & Clinical Immunology, Faculty of 
      Medicine, Ain Shams University, Cairo, Egypt.
FAU - Hegab, Mohammed A
AU  - Hegab MA
AD  - Department of Ophthalmology, Faculty of Medicine, Zagazig University, Zagazig, 
      Egypt.
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - Egypt J Immunol
JT  - The Egyptian journal of immunology
JID - 9816016
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Case-Control Studies
MH  - *Conjunctivitis, Allergic/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
MH  - *Toll-Like Receptor 4/genetics
EDAT- 2022/02/17 06:00
MHDA- 2022/02/19 06:00
CRDT- 2022/02/16 13:20
PHST- 2022/02/16 13:20 [entrez]
PHST- 2022/02/17 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PST - ppublish
SO  - Egypt J Immunol. 2022 Jan;29(1):1-12.