PMID- 35172168
OWN - NLM
STAT- MEDLINE
DCOM- 20220620
LR  - 20230918
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 239
DP  - 2022 Jul
TI  - Pediatric Cataract Surgery Following Treatment for Retinoblastoma: A Case Series 
      and Systematic Review.
PG  - 130-141
LID - S0002-9394(22)00046-0 [pii]
LID - 10.1016/j.ajo.2022.02.001 [doi]
AB  - PURPOSE: To determine the visual and refractive outcomes and the ocular and 
      systemic complications of cataract surgery in eyes treated for retinoblastoma. 
      DESIGN: Retrospective consecutive case series and systematic review. METHODS: 
      Children <18 years of age with retinoblastoma who underwent surgery for secondary 
      cataract between 2000 and 2020 were reviewed. Medline (OVID), Embase, Web of 
      Science, and the Cochrane database were searched from inception to August 2020. 
      RESULTS: A total of 15 eyes of 15 children were included. The mean age at 
      retinoblastoma diagnosis was 12 months (median, 14; interquartile range [IQR], 
      4-19). Cataract developed at a mean age of 39 months (median, 31; IQR, 20-52), 
      secondary to multiple treatments (n = 7), pars-plana vitrectomy (n = 3), 
      external-beam radiotherapy (n = 2), laser (n = 2), and retinal detachment 
      (n = 1). The mean preoperative quiescent interval was 44 months (median, 28; IQR, 
      15-64). Primary intraocular lens implantation was performed in 93%, posterior 
      capsulotomy in 40%, and anterior vitrectomy in 33% of participants. 
      Postoperatively, 100% had improved fundus visibility and 73% had improved vision. 
      Complications included visual axis opacification (11 of 15), capsular phimosis (5 
      of 15), and zonulopathy (3 of 15). No patient developed intraocular recurrence, 
      extraocular extension, or metastasis at a mean of 76 months (median, 78; IQR, 
      29-128) follow-up. The systematic review identified 852 studies, with 18 meeting 
      inclusion criteria. Across all studies (n = 220 children), intraocular recurrence 
      occurred in 6%, globe salvage in 91%, and extraocular extension and metastasis in 
      <1%. CONCLUSIONS: Modern retinoblastoma therapies, including intravitreal 
      chemotherapy and vitrectomy, cause secondary cataract. Following cataract 
      surgery, intraocular recurrence risk is low and extraocular spread is rare. 
      Although surgery improves tumor visualization, visual prognosis may be limited by 
      several factors. Challenges include biometry limitations and a high incidence of 
      zonulopathy.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Kletke, Stephanie N
AU  - Kletke SN
AD  - From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick 
      Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision 
      Sciences, University of Toronto, Toronto, Ontario, Canada.
FAU - Mallipatna, Ashwin
AU  - Mallipatna A
AD  - From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick 
      Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision 
      Sciences, University of Toronto, Toronto, Ontario, Canada.
FAU - Mireskandari, Kamiar
AU  - Mireskandari K
AD  - From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick 
      Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision 
      Sciences, University of Toronto, Toronto, Ontario, Canada.
FAU - Gallie, Brenda L
AU  - Gallie BL
AD  - From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick 
      Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision 
      Sciences, University of Toronto, Toronto, Ontario, Canada.
FAU - Ali, Asim
AU  - Ali A
AD  - From the Department of Ophthalmology and Vision Sciences, The Hospital for Sick 
      Children, Toronto, Ontario, Canada; Department of Ophthalmology and Vision 
      Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address: 
      asim.ali@utoronto.ca.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220213
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - *Capsule Opacification
MH  - *Cataract/complications
MH  - *Cataract Extraction/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Lens Implantation, Intraocular/adverse effects
MH  - Male
MH  - Postoperative Complications
MH  - *Retinal Neoplasms/complications/surgery
MH  - *Retinoblastoma/complications/surgery
MH  - Retrospective Studies
MH  - Visual Acuity
MH  - Vitrectomy/adverse effects
OTO - NOTNLM
OT  - Cataract
OT  - Retinoblastoma
OT  - cataract surgery
EDAT- 2022/02/17 06:00
MHDA- 2022/06/22 06:00
CRDT- 2022/02/16 20:07
PHST- 2021/11/06 00:00 [received]
PHST- 2022/01/23 00:00 [revised]
PHST- 2022/02/02 00:00 [accepted]
PHST- 2022/02/17 06:00 [pubmed]
PHST- 2022/06/22 06:00 [medline]
PHST- 2022/02/16 20:07 [entrez]
AID - S0002-9394(22)00046-0 [pii]
AID - 10.1016/j.ajo.2022.02.001 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2022 Jul;239:130-141. doi: 10.1016/j.ajo.2022.02.001. Epub 2022 
      Feb 13.