PMID- 35172898
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220223
IS  - 2052-1847 (Print)
IS  - 2052-1847 (Electronic)
IS  - 2052-1847 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Feb 16
TI  - Association between matrix metalloproteinase-3 gene polymorphisms and 
      tendon-ligament injuries: evidence from a meta-analysis.
PG  - 26
LID - 10.1186/s13102-022-00421-5 [doi]
LID - 26
AB  - BACKGROUND: Tendon-ligament injuries (TLIs), including Achilles tendinopathy, 
      cruciate ligament injury, tennis elbow, rotator cuff injury, patellar 
      tendinopathy, and tibial tendinopathy, are common musculoskeletal soft injuries 
      during physical activity. Matrix metalloproteinase-3 (MMP-3) gene polymorphisms 
      have been implicated in the etiology of TLIs in several genetic association 
      studies with inconsistent results. The purpose of this study was to collect and 
      synthesize the current evidences on the association of MMP-3 polymorphisms and 
      TLIs. METHODS: The search was conducted using PubMed, Web of Science, EMBASE, 
      Cochrane Library, CNKI and Wanfang databases, prior to July, 2021. Newcastle 
      Ottawa Scale was used to appraise the study quality. Strengths of association 
      were represented by odds ratios (ORs) and 95% confidence intervals (95% CIs). 
      RESULTS: Thirteen studies with 2871 cases and 4497 controls met the eligibility 
      criteria, and each study was in high quality. The overall analyzes suggested 
      rs3025058 was associated with an increased TLIs risk (5A vs. 6A, OR = 1.20, 95% 
      CI 1.03-1.40, P = 0.020). However, the association was not found for rs679620, 
      rs591058, and rs650108 polymorphisms. Subgroup analysis by injury type suggested 
      that rs679620 polymorphism was associated with a reduced risk to Achilles tendon 
      rupture (AA + AG vs. GG, OR = 0.46, 95% CI 0.25-0.87, P = 0.020), and rs3025058 
      was associated with an elevated risk to anterior cruciate ligament injury 
      (5A5A + 5A6A vs. 6A6A, OR = 1.46, 95% CI 1.03-2.06, P = 0.030). When stratified 
      by ethnicity, the findings indicated that rs3025058 polymorphism was associated 
      with an increased TLIs risk among Caucasians (5A6A vs. 6A6A, OR = 1.55, 95% CI 
      1.09-2.42, P = 0.020) and Brazilians (5A5A vs. 5A6A + 6A6A, OR = 2.80, 95% CI 
      1.44-5.45, P = 0.002). CONCLUSION: Findings of this study suggest that rs679620 
      polymorphism is associated with a reduced Achilles tendon rupture risk, and 
      rs3025058 polymorphism contributes to an increased TLIs risk in Caucasians and 
      Brazilians. However, rs591058 and rs650108 polymorphisms do not show any 
      association with TLIs.
CI  - (c) 2022. The Author(s).
FAU - Guo, Rui
AU  - Guo R
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
FAU - Aizezi, Aihaiti
AU  - Aizezi A
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
FAU - Fan, Yong
AU  - Fan Y
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
FAU - Ji, Zhe
AU  - Ji Z
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
FAU - Li, Wenzong
AU  - Li W
AD  - Department of Surgery, People's Hospital of Burqin County, Altay, 836500, 
      Xinjiang, China.
FAU - Li, Yongxian
AU  - Li Y
AD  - Department of Surgery, People's Hospital of Tuoli County, Tacheng, 834300, 
      Xinjiang, China.
FAU - Wang, Zhigang
AU  - Wang Z
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China. rmyygr@126.com.
FAU - Ning, Kai
AU  - Ning K
AD  - Department of Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous 
      Region, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China. 
      13579233099@163.com.
LA  - eng
GR  - 2018D01C120/Natural Science Foundation of Xinjiang Uygur Autonomous Region/
GR  - 2018D01C120/Natural Science Foundation of Xinjiang Uygur Autonomous Region/
PT  - Journal Article
DEP - 20220216
PL  - England
TA  - BMC Sports Sci Med Rehabil
JT  - BMC sports science, medicine & rehabilitation
JID - 101605016
PMC - PMC8851795
OTO - NOTNLM
OT  - Matrix metalloproteinase-3
OT  - Meta-analysis
OT  - Polymorphism
OT  - Tendon-ligament injury
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/18 06:00
MHDA- 2022/02/18 06:01
PMCR- 2022/02/16
CRDT- 2022/02/17 05:29
PHST- 2021/11/13 00:00 [received]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/02/17 05:29 [entrez]
PHST- 2022/02/18 06:00 [pubmed]
PHST- 2022/02/18 06:01 [medline]
PHST- 2022/02/16 00:00 [pmc-release]
AID - 10.1186/s13102-022-00421-5 [pii]
AID - 421 [pii]
AID - 10.1186/s13102-022-00421-5 [doi]
PST - epublish
SO  - BMC Sports Sci Med Rehabil. 2022 Feb 16;14(1):26. doi: 
      10.1186/s13102-022-00421-5.