PMID- 35173222 OWN - NLM STAT- MEDLINE DCOM- 20220314 LR - 20220314 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 12 IP - 1 DP - 2022 Feb 16 TI - Retrospective identification of medication related adverse events in the emergency medical services through the analysis of a patient safety register. PG - 2622 LID - 10.1038/s41598-022-06290-9 [doi] LID - 2622 AB - Adverse drug events encompass a wide range of potential unintended and harmful events, from adverse drug reactions to medication errors, many of which in retrospect, are considered preventable. However, the primary challenge towards reducing their burden lies in consistently identifying and monitoring these occurrences, a challenge faced across the spectrum of healthcare, including the emergency medical services. The aim of this study was to identify and describe medication related adverse events (AEs) in the out-of-hospital setting. The medication components of a dedicated patient safety register were analysed and described for the period Jan 2017-Sept 2020. Univariate descriptive analysis was used to summarize and report on basic case and patient demographics, intervention related AEs, medication related AEs, and AE severity. Multivariable logistic regression was used to assess the odds of AE severity, by AE type. A total of 3475 patient records were assessed where 161 individual medication AEs were found in 150 (4.32%), 12 of which were categorised as harmful. Failure to provide a required medication was found to be the most common error (1.67%), followed by the administration of medications outside of prescribed practice guidelines (1.18%). There was evidence to suggest a 63% increase in crude odds of any AE severity [OR 1.63 (95% CI 1.03-2.6), p = 0.035] with the medication only AEs when compared to the intervention only AEs. Prehospital medication related adverse events remain a significant threat to patient safety in this setting and warrant greater widespread attention and future identification of strategies aimed at their reduction. CI - (c) 2022. The Author(s). FAU - Howard, Ian AU - Howard I AD - Hamad Medical Corporation Ambulance Service, Hamad Medical Corporation, Doha, Qatar. ihoward@hamad.qa. FAU - Howland, Ian AU - Howland I AD - Hamad Medical Corporation Ambulance Service, Hamad Medical Corporation, Doha, Qatar. FAU - Castle, Nicholas AU - Castle N AD - Hamad Medical Corporation Ambulance Service, Hamad Medical Corporation, Doha, Qatar. FAU - Al Shaikh, Loua AU - Al Shaikh L AD - Hamad Medical Corporation Ambulance Service, Hamad Medical Corporation, Doha, Qatar. FAU - Owen, Robert AU - Owen R AD - Hamad Medical Corporation Ambulance Service, Hamad Medical Corporation, Doha, Qatar. LA - eng PT - Journal Article PT - Observational Study DEP - 20220216 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Drug-Related Side Effects and Adverse Reactions/*epidemiology/prevention & control MH - Emergency Medical Services/*supply & distribution MH - Female MH - Humans MH - Logistic Models MH - Male MH - Medication Errors/*statistics & numerical data MH - Middle Aged MH - Outpatients/*statistics & numerical data MH - Patient Safety/*statistics & numerical data MH - *Registries MH - Retrospective Studies MH - Severity of Illness Index MH - Time Factors MH - Young Adult PMC - PMC8850606 COIS- The authors declare no competing interests. EDAT- 2022/02/18 06:00 MHDA- 2022/03/15 06:00 PMCR- 2022/02/16 CRDT- 2022/02/17 05:31 PHST- 2021/09/09 00:00 [received] PHST- 2021/12/22 00:00 [accepted] PHST- 2022/02/17 05:31 [entrez] PHST- 2022/02/18 06:00 [pubmed] PHST- 2022/03/15 06:00 [medline] PHST- 2022/02/16 00:00 [pmc-release] AID - 10.1038/s41598-022-06290-9 [pii] AID - 6290 [pii] AID - 10.1038/s41598-022-06290-9 [doi] PST - epublish SO - Sci Rep. 2022 Feb 16;12(1):2622. doi: 10.1038/s41598-022-06290-9.