PMID- 35174058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2233-8276 (Print)
IS  - 2233-8268 (Electronic)
IS  - 2233-8276 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jan
TI  - Evaluation of the techniques and steps of intranasal corticosteroid sprays 
      administration.
PG  - e7
LID - 10.5415/apallergy.2022.12.e7 [doi]
LID - e7
AB  - BACKGROUND: Intranasal corticosteroid (INCS) is one of the most effective 
      treatments for allergic rhinitis (AR). To achieve optimum efficiency while 
      avoiding adverse effects (AEs), patients must comply with and follow the drug 
      administration instructions. OBJECTIVE: To evaluate INCS administration 
      techniques and steps and the association between inaccurate drug administration 
      and AEs. METHODS: A descriptive cross-sectional study was performed in patients 
      diagnosed with AR who had used an INCS for more than 1 month at the HRH Princess 
      Maha Chakri Sirindhorn Medical Center, Nakhon Nayok, Thailand between September 
      2020 and August 2021. Patient information was collected, evaluate the accuracy of 
      the application techniques and the steps they followed for INCS administration 
      and the occurrence of any associated AEs. RESULTS: In total, 150 subjects 
      diagnosed with AR met the criteria. Only 6 patients (4%) correctly performed all 
      12 steps of INCS administration, while 44 patients (29.33%) correctly performed 
      the 5 recommended essential steps. AEs were found in 23 patients (15.33%), with 
      not pointing the tip slightly outward away from the septum significantly 
      associated with a 3.6 times higher risk of AEs in patients (odds ratio, 3.6; 95% 
      confidence interval, 1.3-9.4; p = 0.012). CONCLUSION: Investigations into INCS 
      use in patients with AR revealed that only 4% of patients correctly performed all 
      the administration techniques and steps, while 30% of patients at least followed 
      the 5 recommended essential steps perfectly. Not pointing the tip slightly 
      outward away from the septum was found to result in the most AEs. TRIAL 
      REGISTRATION: Thai Clinical Trials Registry: TCTR-20210718003.
CI  - Copyright (c) 2022. Asia Pacific Association of Allergy, Asthma and Clinical 
      Immunology.
FAU - Rattanawong, Supachet
AU  - Rattanawong S
AUID- ORCID: 0000-0003-2758-3368
AD  - Department of Otolaryngology, Faculty of Medicine, Srinakharinwirot University, 
      Nakhon Nayok, Thailand.
AD  - Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
FAU - Wongwattana, Panuwat
AU  - Wongwattana P
AUID- ORCID: 0000-0003-1348-0739
AD  - Department of Otolaryngology, Faculty of Medicine, Srinakharinwirot University, 
      Nakhon Nayok, Thailand.
AD  - Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
FAU - Kantukiti, Supatat
AU  - Kantukiti S
AUID- ORCID: 0000-0001-6789-7631
AD  - Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20220124
PL  - Netherlands
TA  - Asia Pac Allergy
JT  - Asia Pacific allergy
JID - 101561954
PMC - PMC8819420
OTO - NOTNLM
OT  - Administration
OT  - Allergic rhinitis
OT  - Intranasal corticosteroid
OT  - Nasal spray
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2022/02/18 06:00
MHDA- 2022/02/18 06:01
PMCR- 2022/01/01
CRDT- 2022/02/17 05:37
PHST- 2021/11/11 00:00 [received]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/17 05:37 [entrez]
PHST- 2022/02/18 06:00 [pubmed]
PHST- 2022/02/18 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.5415/apallergy.2022.12.e7 [doi]
PST - epublish
SO  - Asia Pac Allergy. 2022 Jan 24;12(1):e7. doi: 10.5415/apallergy.2022.12.e7. 
      eCollection 2022 Jan.