PMID- 35174182 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220501 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 8 DP - 2021 TI - Publication Trends of Research on Polypoidal Choroidal Vasculopathy During 2001-2020: A 20-Year Bibliometric Study. PG - 785126 LID - 10.3389/fmed.2021.785126 [doi] LID - 785126 AB - INTRODUCTION: Polypoidal choroidal vasculopathy (PCV) is a special subtype of AMD, which is one of the leading threats to vision health worldwide. At this time, many aspects of PCV, from how it works to potential treatments, remain a mystery. In this study, we explored the frontier researches and revealed the study trends within the study of PCV. METHODS: We collected all the publications in this field from 2001 to 2020, analyzed trends within them, and defined the contributions of various countries/regions, institutions, authors, and journals. Additionally, VOSviewer software was used to define the hot keywords in this field. RESULTS: A total of 1,190 publications were ultimately examined; We found that PCV is becoming an increasingly relevant topic of research, and that Japan has contributed the most publications (428), the most citations (14,504 in total), and the highest H-index value (62) to the field. Our keywords analysis was classified into four clusters to show the hotspots within the study of PCV, namely mechanism-related, imaging-related, prognosis-related, and therapy-related topics. The average years in which the keywords appeared the most were also calculated, and we identified anti-VEGF therapy, anti-complement therapy and angiography as having been the main focus in recent years. CONCLUSIONS: These results helped clarify the comprehensive research progress that has been made as well as the future trends in the study of PCV, which can assist and guide future research. CI - Copyright (c) 2022 Wang, Xie, Zhang, Zhao, Zhu, Wang, Chen, Chen and Sun. FAU - Wang, Yimin AU - Wang Y AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Xie, Minyue AU - Xie M AD - Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Min AU - Zhang M AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Zhao, Xiaohuan AU - Zhao X AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Zhu, Xinyue AU - Zhu X AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Wang, Yuwei AU - Wang Y AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Chen, Yuhong AU - Chen Y AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Chen, Jieqiong AU - Chen J AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. FAU - Sun, Xiaodong AU - Sun X AD - Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - National Clinical Research Center for Eye Disease, Shanghai, China. AD - Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. AD - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20220131 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC8841421 OTO - NOTNLM OT - age-related macular degeneration (AMD) OT - anti-VEGF (vascular endothelial growth factor) OT - bibliometric OT - pigment epithelial detachment OT - polypoidal choroidal vasculopathy (PCV) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/02/18 06:00 MHDA- 2022/02/18 06:01 PMCR- 2022/01/31 CRDT- 2022/02/17 05:37 PHST- 2021/09/28 00:00 [received] PHST- 2021/12/24 00:00 [accepted] PHST- 2022/02/17 05:37 [entrez] PHST- 2022/02/18 06:00 [pubmed] PHST- 2022/02/18 06:01 [medline] PHST- 2022/01/31 00:00 [pmc-release] AID - 10.3389/fmed.2021.785126 [doi] PST - epublish SO - Front Med (Lausanne). 2022 Jan 31;8:785126. doi: 10.3389/fmed.2021.785126. eCollection 2021.