PMID- 35175337
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20240413
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 71
IP  - 5
DP  - 2022 May 1
TI  - MRI Metrics of Cerebral Endothelial Cell-Derived Exosomes for the Treatment of 
      Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes.
PG  - 873-880
LID - 10.2337/db21-0754 [doi]
AB  - Ongoing neurovascular dysfunction contributes to type 2 diabetes mellitus 
      (T2DM)-induced cognitive deficits. However, it is not known whether early post 
      onset of T2DM interventions may reduce evolving neurovascular dysfunction and 
      thereby lead to diminution of T2DM-induced cognitive deficits. Using multiple MRI 
      metrics, we evaluated neurovascular changes in T2DM rats treated with exosomes 
      derived from cerebral endothelial cells (CEC-Exos). Two months after induction of 
      T2DM in middle-aged male rats by administration of streptozotocin nicotinamide, 
      rats were randomly treated with CEC-Exos twice weekly or saline for 4 consecutive 
      weeks (n = 10/group). MRI measurements were performed at the end of the 
      treatment, which included cerebral blood flow (CBF), contrast-enhanced 
      T1-weighted imaging, and relaxation time constants T1 and T2. MRI analysis showed 
      that compared with controls, the CEC-Exo-treated T2DM rats exhibited significant 
      elevation of T2 and CBF in white matter and significant augmentation of T1 and 
      reduction of blood-brain barrier permeability in gray matter. In the hippocampus, 
      CEC-Exo treatment significantly increased T1 and CBF. Furthermore, CEC-Exo 
      treatment significantly reduced T2DM-induced cognitive deficits measured by the 
      Morris water maze and odor recognition tests. Collectively, our corresponding MRI 
      data demonstrate that treatment of T2DM rats with CEC-Exos robustly reduced 
      neurovascular dysfunction in gray and white matter and the hippocampus.
CI  - (c) 2022 by the American Diabetes Association.
FAU - Ding, Guangliang
AU  - Ding G
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Li, Lian
AU  - Li L
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Chopp, Michael
AU  - Chopp M
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
AD  - Department of Physics, Oakland University, Rochester, MI.
FAU - Davoodi-Bojd, Esmaeil
AU  - Davoodi-Bojd E
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Li, Qingjiang
AU  - Li Q
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Li, Chao
AU  - Li C
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Wei, Min
AU  - Wei M
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Zhang, Zhenggang
AU  - Zhang Z
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
FAU - Jiang, Quan
AU  - Jiang Q
AUID- ORCID: 0000-0001-7908-4443
AD  - Department of Neurology, Henry Ford Hospital, Detroit, MI.
AD  - Department of Physics, Oakland University, Rochester, MI.
LA  - eng
GR  - RF1 AG057494/AG/NIA NIH HHS/United States
GR  - R01 NS108463/NS/NINDS NIH HHS/United States
GR  - R01 AG068072/AG/NIA NIH HHS/United States
GR  - R56 AG055583/AG/NIA NIH HHS/United States
GR  - R01 NS079612/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
MH  - Aging
MH  - Animals
MH  - Benchmarking
MH  - *Cognitive Dysfunction/etiology/therapy
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Endothelial Cells
MH  - *Exosomes
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Rats
PMC - PMC9044132
EDAT- 2022/02/18 06:00
MHDA- 2022/04/23 06:00
PMCR- 2023/05/01
CRDT- 2022/02/17 12:25
PHST- 2021/08/29 00:00 [received]
PHST- 2022/02/10 00:00 [accepted]
PHST- 2022/02/18 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2022/02/17 12:25 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - 144591 [pii]
AID - 210754 [pii]
AID - 10.2337/db21-0754 [doi]
PST - ppublish
SO  - Diabetes. 2022 May 1;71(5):873-880. doi: 10.2337/db21-0754.