PMID- 35175572
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2193-8210 (Print)
IS  - 2190-9172 (Electronic)
VI  - 12
IP  - 3
DP  - 2022 Mar
TI  - Effectiveness of Cimetidine as Adjuvant Therapy in the Treatment of 
      Acute-Extrinsic Atopic Dermatitis: A Double-Blind Randomized Controlled Trial.
PG  - 715-726
LID - 10.1007/s13555-022-00688-z [doi]
AB  - INTRODUCTION: Acute extrinsic atopic dermatitis (AD) requires long-term 
      treatment. Cimetidine could be used as an adjuvant therapy for acute-extrinsic AD 
      due to immunomodulatory effects. This study aims to assess the effectiveness of 
      cimetidine as an adjuvant to standard treatment in acute extrinsic AD. METHODS: 
      This is a double-blind randomized controlled trial involving 26 AD patients aged 
      12-60 years from 2017 to 2020. Effectiveness of cimetidine was assessed by 
      comparing SCORing Atopic Dermatitis (SCORAD) and objective SCORAD changes in both 
      groups at week 2, 4, 6, and 8. Serum levels of immunoglobulin E (IgE), interferon 
      (IFN)-gamma, interleukin (IL)-12, and IL-4 were also documented. RESULTS: Significant 
      differences were observed in SCORAD changes at week 2, 4, 6, and 8 (p = 0.004; 
      p = 0.001; p < 0.001; and p < 0.001 respectively), objective SCORAD changes at 
      week 2, 4, 6, and 8 (p = 0.004, p = 0.001, p < 0.001, and p < 0.001 
      respectively), and IgE level changes at week 8 (p = 0.002) between the two 
      groups. However, there were no significant changes in IFN-gamma, IL-12, and IL-4 
      levels between the two groups. CONCLUSION: Cimetidine is a safe and effective 
      adjuvant therapy for acute-extrinsic AD. TRIAL REGISTRATION: NCT04018131.
CI  - (c) 2022. The Author(s).
FAU - Novianto, Endi
AU  - Novianto E
AUID- ORCID: 0000-0002-8688-4948
AD  - Department of Dermatology and Venereology, Faculty of Medicine Universitas 
      Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, 6 Salemba 
      Raya, Central Jakarta, Jakarta, 10430, Indonesia. drendinovianto@gmail.com.
FAU - Jacoeb, Tjut N A
AU  - Jacoeb TNA
AD  - Department of Dermatology and Venereology, Faculty of Medicine Universitas 
      Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, 6 Salemba 
      Raya, Central Jakarta, Jakarta, 10430, Indonesia.
FAU - Indriatmi, Wresti
AU  - Indriatmi W
AD  - Department of Dermatology and Venereology, Faculty of Medicine Universitas 
      Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, 6 Salemba 
      Raya, Central Jakarta, Jakarta, 10430, Indonesia.
FAU - Suhendro
AU  - Suhendro
AD  - Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. 
      Cipto Mangunkusumo National Central General Hospital, 6 Salemba Raya, Central 
      Jakarta, Jakarta, 10430, Indonesia.
FAU - Setiabudy, Rianto
AU  - Setiabudy R
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas 
      Indonesia, 6 Salemba Raya, Central Jakarta, Jakarta, 10430, Indonesia.
FAU - Setiabudy, Rahajuningsih D
AU  - Setiabudy RD
AD  - Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Dr. 
      Cipto Mangunkusumo National Central General Hospital, 6 Salemba Raya, Central 
      Jakarta, Jakarta, 10430, Indonesia.
FAU - Abdullah, Murdani
AU  - Abdullah M
AD  - Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. 
      Cipto Mangunkusumo National Central General Hospital, 6 Salemba Raya, Central 
      Jakarta, Jakarta, 10430, Indonesia.
FAU - Rengganis, Iris
AU  - Rengganis I
AD  - Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. 
      Cipto Mangunkusumo National Central General Hospital, 6 Salemba Raya, Central 
      Jakarta, Jakarta, 10430, Indonesia.
FAU - Suwarsa, Oki
AU  - Suwarsa O
AD  - Department of Dermatology and Venereology, Faculty of Medicine Universitas 
      Padjajaran, Hasan Sadikin General Hospital, 38 Pasteur, Bandung, 40161, West 
      Java, Indonesia.
FAU - Soebaryo, Retno W
AU  - Soebaryo RW
AD  - Department of Dermatology and Venereology, Faculty of Medicine Universitas 
      Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, 6 Salemba 
      Raya, Central Jakarta, Jakarta, 10430, Indonesia.
LA  - eng
SI  - ClinicalTrials.gov/NCT04018131
PT  - Journal Article
DEP - 20220217
PL  - Switzerland
TA  - Dermatol Ther (Heidelb)
JT  - Dermatology and therapy
JID - 101590450
PMC - PMC8940995
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Cimetidine
OT  - Efficacy
OT  - IgE level
OT  - SCORAD
EDAT- 2022/02/18 06:00
MHDA- 2022/02/18 06:01
PMCR- 2022/02/17
CRDT- 2022/02/17 12:28
PHST- 2021/12/14 00:00 [received]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/02/18 06:00 [pubmed]
PHST- 2022/02/18 06:01 [medline]
PHST- 2022/02/17 12:28 [entrez]
PHST- 2022/02/17 00:00 [pmc-release]
AID - 10.1007/s13555-022-00688-z [pii]
AID - 688 [pii]
AID - 10.1007/s13555-022-00688-z [doi]
PST - ppublish
SO  - Dermatol Ther (Heidelb). 2022 Mar;12(3):715-726. doi: 10.1007/s13555-022-00688-z. 
      Epub 2022 Feb 17.