PMID- 35177781
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20230107
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb 17
TI  - Retinal layer assessments as potential biomarkers for brain atrophy in the 
      Rhineland Study.
PG  - 2757
LID - 10.1038/s41598-022-06821-4 [doi]
LID - 2757
AB  - Retinal assessments have been discussed as biomarkers for brain atrophy. However, 
      available studies did not investigate all retinal layers due to older technology, 
      reported inconsistent results, or were based on small sample sizes. We included 
      2872 eligible participants of the Rhineland Study with data on spectral 
      domain-optical coherence tomography (SD-OCT) and brain magnetic resonance imaging 
      (MRI). We used multiple linear regression to examine relationships between 
      retinal measurements and volumetric brain measures as well as fractional 
      anisotropy (FA) as measure of microstructural integrity of white matter (WM) for 
      different brain regions. Mean (SD) age was 53.8 +/- 13.2 years (range 30-94) and 
      57% were women. Volumes of the inner retina were associated with total brain and 
      grey matter (GM) volume, and even stronger with WM volume and FA. In contrast, 
      the outer retina was mainly associated with GM volume, while both, inner and 
      outer retina, were associated with hippocampus volume. While we extend previously 
      reported associations between the inner retina and brain measures, we found 
      additional associations of the outer retina with parts of the brain. This 
      indicates that easily accessible retinal SD-OCT assessments may serve as 
      biomarkers for clinical monitoring of neurodegenerative diseases and merit 
      further research.
CI  - (c) 2022. The Author(s).
FAU - Mauschitz, Matthias M
AU  - Mauschitz MM
AD  - Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), 
      Venusberg-Campus 1/99, 53127, Bonn, Germany.
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Lohner, Valerie
AU  - Lohner V
AD  - Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), 
      Venusberg-Campus 1/99, 53127, Bonn, Germany.
FAU - Koch, Alexandra
AU  - Koch A
AD  - Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), 
      Venusberg-Campus 1/99, 53127, Bonn, Germany.
FAU - Stocker, Tony
AU  - Stocker T
AD  - MR Physics, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
AD  - Department of Physics and Astronomy, University of Bonn, Bonn, Germany.
FAU - Reuter, Martin
AU  - Reuter M
AD  - Image Analysis, German Center for Neurodegenerative Diseases (DZNE), Bonn, 
      Germany.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Finger, Robert P
AU  - Finger RP
AD  - Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.
FAU - Breteler, Monique M B
AU  - Breteler MMB
AD  - Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), 
      Venusberg-Campus 1/99, 53127, Bonn, Germany. Monique.Breteler@dzne.de.
AD  - Institute for Medical Biometry, Informatics and Epidemiology, Faculty of 
      Medicine, University of Bonn, Bonn, Germany. Monique.Breteler@dzne.de.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20220217
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Atrophy
MH  - Brain Diseases/*diagnostic imaging
MH  - Female
MH  - Gray Matter/*diagnostic imaging
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retina/*diagnostic imaging
MH  - *Tomography, Optical Coherence
MH  - White Matter/*diagnostic imaging
PMC - PMC8854401
COIS- The authors declare no competing interests.
EDAT- 2022/02/19 06:00
MHDA- 2022/03/11 06:00
PMCR- 2022/02/17
CRDT- 2022/02/18 05:43
PHST- 2021/08/31 00:00 [received]
PHST- 2022/01/20 00:00 [accepted]
PHST- 2022/02/18 05:43 [entrez]
PHST- 2022/02/19 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/02/17 00:00 [pmc-release]
AID - 10.1038/s41598-022-06821-4 [pii]
AID - 6821 [pii]
AID - 10.1038/s41598-022-06821-4 [doi]
PST - epublish
SO  - Sci Rep. 2022 Feb 17;12(1):2757. doi: 10.1038/s41598-022-06821-4.