PMID- 35178302
OWN - NLM
STAT- MEDLINE
DCOM- 20230109
LR  - 20230209
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 10
DP  - 2022
TI  - BIRC5 promotes cancer progression and predicts prognosis in laryngeal squamous 
      cell carcinoma.
PG  - e12871
LID - 10.7717/peerj.12871 [doi]
LID - e12871
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) remains one of the most 
      common respiratory tumors worldwide. Baculoviral inhibitor of apoptosis repeat 
      containing 5 (BIRC5) is a member of the inhibitor-of-apoptosis protein family. 
      BIRC5 plays an important role in various types of cell proliferation, 
      differentiation, migration and invasion. However, the specific role of BIRC5 in 
      LSCC remains unclear. METHODS: To provide a prognostic biomarker for LSCC, we 
      screened the prognostic genes of LSCC via bioinformatics. PPI network and KEGG 
      pathways were used to select hub genes. Clinical prognoses were performed using a 
      Kaplan-Meier plotter and Cox proportional-hazard analysis. BIRC5 expression in 
      LSCC tissues and cell lines were detected by RT-PCR, Western blot and 
      Immunohistochemistry (IHC). Cell proliferation, cell cycle and cell apoptosis 
      were detected with Cell Counting Kit-8 (CCK-8) and Flow Cytometry assay, 
      respectively. RESULTS: Here, BIRC5 was strongly correlated with higher tumor 
      grade and differentiation. BIRC5 was highly expressed in LSCC tissues when 
      compared with normal tissues and increased expression of BIRC5 was associated 
      with overall survival in LSCC patients. The suppression of BIRC5 induced cell 
      apoptosis and cell cycle arrest, thereby inhibiting the proliferation of LSCC 
      cells. The survival analysis confirmed that higher level of BIRC5 expression 
      predicted poor prognosis of LSCC patients. BIRC5 may act as an oncogene of LSCC 
      development and was suggested as a promising prognostic biomarker for LSCC.
CI  - (c) 2022 Wang et al.
FAU - Wang, Nan
AU  - Wang N
AD  - Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of 
      Characteristic Agricultural Resources in Mountains Areas, School of Life Science 
      of Jiaying University, Meizhou, China.
FAU - Huang, Xuanyu
AU  - Huang X
AD  - Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of 
      Characteristic Agricultural Resources in Mountains Areas, School of Life Science 
      of Jiaying University, Meizhou, China.
FAU - Cheng, Jinsheng
AU  - Cheng J
AD  - Henry-Fork School of Food Sciences, Shaoguan University, Shaoguan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220201
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
RN  - 0 (Biomarkers)
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Survivin)
MH  - Humans
MH  - Squamous Cell Carcinoma of Head and Neck/genetics
MH  - *Laryngeal Neoplasms/genetics
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Prognosis
MH  - Neoplastic Processes
MH  - *Head and Neck Neoplasms
MH  - Biomarkers
MH  - Survivin/genetics
PMC - PMC8815368
OTO - NOTNLM
OT  - BIRC5
OT  - Bioinformatics
OT  - Cell apoptosis
OT  - Laryngeal squamous cell carcinoma
OT  - Prognosis
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/19 06:00
MHDA- 2022/02/19 06:01
PMCR- 2022/02/01
CRDT- 2022/02/18 05:50
PHST- 2021/07/09 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/02/18 05:50 [entrez]
PHST- 2022/02/19 06:00 [pubmed]
PHST- 2022/02/19 06:01 [medline]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 12871 [pii]
AID - 10.7717/peerj.12871 [doi]
PST - epublish
SO  - PeerJ. 2022 Feb 1;10:e12871. doi: 10.7717/peerj.12871. eCollection 2022.