PMID- 35179821 OWN - NLM STAT- MEDLINE DCOM- 20221014 LR - 20221214 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 56 IP - 5 DP - 2022 Nov TI - Impact of Type 2 Diabetes Mellitus on Epicardial Adipose Tissue and Myocardial Microcirculation by MRI in Postmenopausal Women. PG - 1404-1413 LID - 10.1002/jmri.28121 [doi] AB - BACKGROUND: Type 2 diabetes mellitus (T2DM) often occurs conjunctly with the menopausal transition in female patients. In addition, epicardial adipose tissue (EAT) has an unfavorable impact on the myocardium and coronary arteries under the influence of metabolic disorders. PURPOSE: To investigate the impact of T2DM on EAT and myocardial microvascular function in postmenopausal women. STUDY TYPE: Retrospective. POPULATION: One-hundred sixty-one postmenopausal women divided into three groups: newly diagnosed (5 years) T2DM (n = 57, 61.9 +/- 7.9 years), and healthy controls (n = 48, 59.4 +/- 7.4 years). FIELD STRENGTH/SEQUENCE: 3.0 T; balanced steady-state free precession and inversion recovery prepared echo-planar sequences. ASSESSMENT: EAT volume was quantified by delineating the epicardial border and the visceral layer of pericardium on the short-axis cine stacks. Perfusion parameters including upslope, maximum signal intensity (MaxSI) and time to maximum signal intensity (TTM) were derived from the first-pass perfusion signal intensity-time curves. STATISTICAL TESTS: One-way analysis of variance, Pearson's and Spearman correlation, and multivariable linear regression. Two-sided P < 0.05 was considered statistically significant. RESULTS: EAT volume was significantly increased in diabetic postmenopausal women compared to the controls (48.4 +/- 13.4 mL/m(2) [newly diagnosed T2DM] vs. 58.4 +/- 17.3 mL/m(2) [long-term T2DM] vs. 35.8 +/- 12.3 mL/m(2) [controls]). Regarding perfusion parameters, upslope and MaxSI were significantly reduced (2.6 +/- 1.0 [newly diagnosed T2DM] vs. 2.1 +/- 0.8 [long-term T2DM] vs. 3.6 +/- 1.3 [controls]; and 21.4 +/- 6.9 [newly diagnosed T2DM] vs. 18.7 +/- 6.4 [long-term T2DM] vs. 28.4 +/- 8.6 [controls]), whereas TTM was significantly increased in the T2DM groups compared to the control group (23.6 +/- 8.7 [newly diagnosed T2DM] vs. 27.1 +/- 9.4 [long-term T2DM] vs. 21.4 +/- 6.0 [controls]). Multivariable analysis (adjusted coefficient of determination [R(2) ] = 0.489) showed that EAT volume (beta = -0.610) and menopausal age (beta = 0.433) were independently correlated with decreased perfusion upslope. DATA CONCLUSION: Diabetic postmenopausal women had significantly higher EAT volume and more impaired microcirculation compared to the controls. Increased EAT volume and earlier menopausal age were independently associated with microvascular dysfunction in these patients. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 3. CI - (c) 2022 International Society for Magnetic Resonance in Medicine. FAU - Huang, Shan AU - Huang S AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Yuan AU - Li Y AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Jiang, Li AU - Jiang L AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Ren, Yan AU - Ren Y AD - Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Jin AU - Wang J AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Shi, Ke AU - Shi K AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Yan, Wei-Feng AU - Yan WF AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Qian, Wen-Lei AU - Qian WL AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Yang, Zhi-Gang AU - Yang ZG AUID- ORCID: 0000-0001-9341-7697 AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220218 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 SB - IM CIN - J Magn Reson Imaging. 2022 Nov;56(5):1414-1415. PMID: 35347803 MH - Adipose Tissue/diagnostic imaging/metabolism MH - *Diabetes Mellitus, Type 2/complications MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Microcirculation MH - Myocardium/metabolism MH - Pericardium/diagnostic imaging MH - Postmenopause MH - Retrospective Studies OTO - NOTNLM OT - diabetes OT - epicardial adipose tissue OT - myocardial microcirculation OT - postmenopause EDAT- 2022/02/19 06:00 MHDA- 2022/10/15 06:00 CRDT- 2022/02/18 12:16 PHST- 2022/02/07 00:00 [revised] PHST- 2022/01/18 00:00 [received] PHST- 2022/02/09 00:00 [accepted] PHST- 2022/02/19 06:00 [pubmed] PHST- 2022/10/15 06:00 [medline] PHST- 2022/02/18 12:16 [entrez] AID - 10.1002/jmri.28121 [doi] PST - ppublish SO - J Magn Reson Imaging. 2022 Nov;56(5):1404-1413. doi: 10.1002/jmri.28121. Epub 2022 Feb 18.