PMID- 35180463
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20220531
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 70
DP  - 2022 Apr
TI  - Schizophrenia after remission of anti-NMDA receptor encephalitis.
PG  - 103027
LID - S1876-2018(22)00025-9 [pii]
LID - 10.1016/j.ajp.2022.103027 [doi]
AB  - N-methyl-D-aspartate receptor (NMDAR) dysfunction is an attractive hypothesis 
      regarding the etiology of schizophrenia. We present the unprecedented case of a 
      woman diagnosed with schizophrenia without anti-NMDAR antibodies after history of 
      NMDAR encephalitis. A first episode of psychosis was antibody-positive and was 
      improved with steroid and immunoglobulin treatment. Second and third episodes 
      were antibody-negative, each about three months postpartum (different 
      pregnancies) and were improved with antipsychotics. Without NMDAR 
      encephalitis-related findings, we diagnosed schizophrenia. After anti-NMDAR 
      encephalitis, NMDAR dysfunction may decrease the threshold for the onset of 
      psychosis. This case provides insight into NMDAR dysfunction on etiology of 
      schizophrenia.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Yasuda, Kasumi
AU  - Yasuda K
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, 
      Wakayama, Wakayama 641-8510, Japan. Electronic address: 
      y-kasumi@wakayama-med.ac.jp.
FAU - Uenishi, Shinya
AU  - Uenishi S
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, 
      Wakayama, Wakayama 641-8510, Japan; Department of Psychiatry, Hidaka Hospital, 
      116-2 Sono, Gobo, Wakayama 644-0002, Japan.
FAU - Sakamoto, Hiroshi
AU  - Sakamoto H
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, 
      Wakayama, Wakayama 641-8510, Japan; Department of Psychiatry, Wakayama 
      Prefectural Mental Health Care Center, 31 Sho, Aridagawa, Wakayama 643-0831, 
      Japan.
FAU - Hori, Kohei
AU  - Hori K
AD  - Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 
      Wakayama 641-8510, Japan.
FAU - Koh, Jinsoo
AU  - Koh J
AD  - Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 
      Wakayama 641-8510, Japan.
FAU - Takahashi, Shun
AU  - Takahashi S
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera, 
      Wakayama, Wakayama 641-8510, Japan; Clinical Research and Education Center, 
      Asakayama General Hospital, 3-3-16 Imaike-chou, Sakai-ku, Sakai, Osaka 590-0018, 
      Japan; Graduate School of Comprehensive Rehabilitation, Osaka Prefecture 
      University, 3-7-30 Habikino, Habikino, Osaka 583-8555, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220212
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications/diagnosis/drug 
      therapy
MH  - *Antipsychotic Agents/therapeutic use
MH  - Female
MH  - Humans
MH  - *Psychotic Disorders/drug therapy/etiology
MH  - Receptors, N-Methyl-D-Aspartate
MH  - *Schizophrenia/complications/drug therapy
OTO - NOTNLM
OT  - NMDA receptor
OT  - NMDAR encephalitis
OT  - Schizophrenia
EDAT- 2022/02/19 06:00
MHDA- 2022/03/16 06:00
CRDT- 2022/02/18 20:09
PHST- 2021/11/12 00:00 [received]
PHST- 2022/01/05 00:00 [revised]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/02/19 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2022/02/18 20:09 [entrez]
AID - S1876-2018(22)00025-9 [pii]
AID - 10.1016/j.ajp.2022.103027 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2022 Apr;70:103027. doi: 10.1016/j.ajp.2022.103027. Epub 2022 
      Feb 12.