PMID- 35180824
OWN - NLM
STAT- MEDLINE
DCOM- 20220222
LR  - 20220222
IS  - 1336-0329 (Electronic)
IS  - 1210-0668 (Linking)
VI  - 56
IP  - 1
DP  - 2022 Feb 18
TI  - Insulin receptor substrate 1 gene variations and lipid profile characteristics in 
      the type 2 diabetic patients with comorbid obesity and chronic pancreatitis.
PG  - 1-9
LID - 10.2478/enr-2022-0001 [doi]
AB  - Objective. Type 2 diabetes mellitus (T2DM) is one of diseases that develops in a 
      setting of polymorbid processes or more often promotes their development, forming 
      in this spectrum the phenomenon of comorbidity. The aim of this study was to 
      evaluate changes in the lipid panel data in T2DM patients with comorbid obesity 
      and chronic pancreatitis (CP) taking into account the C/A polymorphism of the 
      insulin receptor substrate 1 (IRS1) gene (rs2943640). Methods. The study involved 
      34 T2DM patients and 10 healthy individuals. The rs2943640 IRS1 gene polymorphism 
      was genotyped using the TaqMan real-time polymerase chain reaction (PCR) method. 
      Blood serum lipid panel data were determined with commercially available kits on 
      a Cobas 6000 analyzer. Results. In patients with only T2DM and T2DM + comorbid 
      obesity, an association between IRS1 gene polymorphism (rs2943640) and lipid 
      profile abnormalities with maximum changes of the lipid characteristics recorded 
      in C/C genotype carriers was found. Within the C/C genotype of the IRS1 gene 
      (rs2943640) in type 2 diabetic patients with comorbid obesity and CP, 
      significantly lower high-density lipoprotein cholesterol (HDL-C) levels and 
      significantly higher levels of triglycerides (TG), non-HDL-C and remnant 
      cholesterol (RC) in relation to type 2 diabetic patients with comorbid obesity 
      were found. At the same time, within the C/A genotype of the IRS1 gene 
      (rs2943640), significant changes of lipid panel data were found in type 2 
      diabetic patients with comorbid obesity relative to the control group (p<0.001). 
      Conclusions. Our data indicate that the presence of the C allele of IRS1 gene 
      (rs2943640) in both homozygous and heterozygous states may indicate increased 
      risk of dyslipidemia in type 2 diabetic patients with comorbidities.
CI  - (c) 2022 Mariya Marushchak et al., published by Sciendo.
FAU - Marushchak, Mariya
AU  - Marushchak M
AD  - Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil 
      National Medical University, Ternopil, Ukraine.
FAU - Hevko, Uliana
AU  - Hevko U
AD  - Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil 
      National Medical University, Ternopil, Ukraine.
FAU - Krynytska, Inna
AU  - Krynytska I
AD  - Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil 
      National Medical University, Ternopil, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20220218
PL  - Germany
TA  - Endocr Regul
JT  - Endocrine regulations
JID - 9112018
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Insulin Receptor Substrate Proteins)
SB  - IM
MH  - Cholesterol, HDL
MH  - Comorbidity
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Humans
MH  - Insulin Receptor Substrate Proteins/genetics
MH  - Obesity/epidemiology/genetics
MH  - *Pancreatitis, Chronic
OTO - NOTNLM
OT  - IRS1 gene
OT  - comorbidities
OT  - lipid profile
OT  - type 2 diabetes mellitus
EDAT- 2022/02/19 06:00
MHDA- 2022/02/23 06:00
CRDT- 2022/02/18 20:16
PHST- 2022/02/19 06:00 [pubmed]
PHST- 2022/02/23 06:00 [medline]
PHST- 2022/02/18 20:16 [entrez]
AID - enr-2022-0001 [pii]
AID - 10.2478/enr-2022-0001 [doi]
PST - epublish
SO  - Endocr Regul. 2022 Feb 18;56(1):1-9. doi: 10.2478/enr-2022-0001.