PMID- 35181747
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb 18
TI  - Association between depression and anxiety on symptom and function after surgery 
      for lumbar spinal stenosis.
PG  - 2821
LID - 10.1038/s41598-022-06797-1 [doi]
LID - 2821
AB  - Evidence on the role of depression and anxiety in patients undergoing surgical 
      treatment for symptomatic degenerative lumbar spinal stenosis (DLSS) is 
      conflicting. We aimed to assess the association between depression and anxiety 
      with symptoms and function in patients undergoing surgery for DLSS. Included were 
      patients with symptomatic DLSS participating in a prospective multicentre cohort 
      study who underwent surgery and completed the 24-month follow-up. We used the 
      hospital anxiety and depression scale (HADS) to assess depression/anxiety. We 
      used mixed-effects models to quantify the impact on the primary outcome change in 
      the spinal stenosis measure (SSM) symptoms/function subscale from baseline to 12- 
      and 24-months. Logistic regression analysis was used to quantify the odds of the 
      SSM to reach a minimal clinically important difference (MCID) at 24 months 
      follow-up. The robustness of the results in the presence of unmeasured 
      confounding was quantified using a benchmarking method based on a multiple linear 
      model. Out of 401 patients 72 (17.95%) were depressed and 80 anxious (19.05%). 
      Depression was associated with more symptoms (beta = 0.36, 95% confidence interval 
      (CI) 0.20 to 0.51, p < 0.001) and worse function (beta = 0.37, 95% CI 0.24 to 0.50, 
      p < 0.001) at 12- and 24-months. Only the association between baseline depression 
      and SSM symptoms/function was robust at 12 and 24 months. There was no evidence 
      for baseline depression/anxiety decreasing odds for a MCID in SSM symptoms and 
      function over time. In patients undergoing surgery for symptomatic DLSS, 
      preoperative depression but not anxiety was associated with more severe symptoms 
      and disability at 12 and 24 months.
CI  - (c) 2022. The Author(s).
FAU - Held, U
AU  - Held U
AD  - Department of Biostatistics at Epidemiology, Biostatistics and Prevention 
      Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland.
FAU - Burgstaller, J M
AU  - Burgstaller JM
AD  - Department of Internal Medicine, Horten Centre for Patient Oriented Research and 
      Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, 8032, Zurich, 
      Switzerland.
AD  - Institute of Primary Care, University and University Hospital Zurich, 
      Pestalozzistrasse 24, 8032, Zurich, Switzerland.
FAU - Deforth, M
AU  - Deforth M
AD  - Department of Biostatistics at Epidemiology, Biostatistics and Prevention 
      Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland.
FAU - Steurer, J
AU  - Steurer J
AD  - Department of Internal Medicine, Horten Centre for Patient Oriented Research and 
      Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, 8032, Zurich, 
      Switzerland.
FAU - Pichierri, G
AU  - Pichierri G
AD  - Department of Internal Medicine, Horten Centre for Patient Oriented Research and 
      Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, 8032, Zurich, 
      Switzerland.
AD  - Institute of Primary Care, University and University Hospital Zurich, 
      Pestalozzistrasse 24, 8032, Zurich, Switzerland.
FAU - Wertli, M M
AU  - Wertli MM
AD  - Department of Internal Medicine, Horten Centre for Patient Oriented Research and 
      Knowledge Transfer, University of Zurich, Pestalozzistrasse 24, 8032, Zurich, 
      Switzerland. Maria.Wertli@insel.ch.
AD  - Department of General Internal Medicine, Kantonsspital Baden, Im Ergel 1, 5404, 
      Baden, Switzerland. Maria.Wertli@insel.ch.
AD  - Division of General Internal Medicine, Bern University Hospital, University of 
      Bern, Freiburgstrasse 16p, 3010, Bern, Switzerland. Maria.Wertli@insel.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220218
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Anxiety Disorders/*epidemiology/etiology/pathology/psychology
MH  - Decompression, Surgical/adverse effects
MH  - Depression/*epidemiology/etiology/pathology/psychology
MH  - Disabled Persons
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Lumbar Vertebrae/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Minimal Clinically Important Difference
MH  - Spinal Stenosis/*complications/pathology/psychology/surgery
MH  - Treatment Outcome
PMC - PMC8857319
COIS- The authors declare no competing interests.
EDAT- 2022/02/20 06:00
MHDA- 2022/03/11 06:00
PMCR- 2022/02/18
CRDT- 2022/02/19 05:29
PHST- 2021/06/05 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/19 05:29 [entrez]
PHST- 2022/02/20 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2022/02/18 00:00 [pmc-release]
AID - 10.1038/s41598-022-06797-1 [pii]
AID - 6797 [pii]
AID - 10.1038/s41598-022-06797-1 [doi]
PST - epublish
SO  - Sci Rep. 2022 Feb 18;12(1):2821. doi: 10.1038/s41598-022-06797-1.