PMID- 35182053 OWN - NLM STAT- MEDLINE DCOM- 20220426 LR - 20220716 IS - 2198-3844 (Electronic) IS - 2198-3844 (Linking) VI - 9 IP - 12 DP - 2022 Apr TI - Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration. PG - e2105727 LID - 10.1002/advs.202105727 [doi] LID - 2105727 AB - Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study, a bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair-derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration has been developed. The prepared bioscaffold with multi-mimetic enzyme effects, which can scavenge a broad spectrum of free radicals in OA, can protect chondrocytes under the ROS microenvironment. Importantly, the bioscaffold can distinctly stimulate the proliferation and maturation of chondrocytes due to the stimulation of the glucose transporter pathway (GLUT) via HNPs/HMPs. Furthermore, it significantly accelerated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results showed that the bioscaffold can effectively enhance the osteochondral regeneration compared to the unmodified scaffold. The work shows that integration of antioxidant and mechanical properties via the bioscaffold is a promising strategy for osteochondral regeneration in OA treatment. CI - (c) 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. FAU - Deng, Cuijun AU - Deng C AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. AD - Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, P.R. China. FAU - Zhou, Quan AU - Zhou Q AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. FAU - Zhang, Meng AU - Zhang M AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. FAU - Li, Tian AU - Li T AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. FAU - Chen, Haotian AU - Chen H AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. AD - Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, P.R. China. FAU - Xu, Chang AU - Xu C AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. FAU - Feng, Qishuai AU - Feng Q AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. FAU - Wang, Xin AU - Wang X AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. FAU - Yin, Feng AU - Yin F AD - Department of Joint Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, P.R. China. FAU - Cheng, Yu AU - Cheng Y AUID- ORCID: 0000-0002-9030-2023 AD - Translational Medical Center for Stem Cell Therapy & Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, P.R. China. FAU - Wu, Chengtie AU - Wu C AD - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China. LA - eng GR - 2018YFC1105201/National Key Research and Development Program of China/ GR - SQ2021YFA1200083/National Key Research and Development Program of China/ GR - 31870997/National Natural Science Foundation of China/ GR - 51761135103/National Natural Science Foundation of China/ GR - 82102196/National Natural Science Foundation of China/ GR - JCTD-2018-13/Innovation Cross Team of Chinese Academy Sciences/ GR - 20214Y0041/Science Project of Shanghai Municipal Health Commission/ GR - 2017-01-07-00-07-E00038/Shanghai Municipal Education Commission Innovative Program/ GR - 19YF1450700/Shanghai Sailing Program/ GR - 19YF1450900/Shanghai Sailing Program/ GR - 20dz1101200/Science and Technology Commission Foundation of Shanghai/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220219 PL - Germany TA - Adv Sci (Weinh) JT - Advanced science (Weinheim, Baden-Wurttemberg, Germany) JID - 101664569 RN - 0 (Antioxidants) RN - 0 (Reactive Oxygen Species) SB - IM MH - Antioxidants/pharmacology MH - *Mesenchymal Stem Cells MH - *Osteogenesis MH - Reactive Oxygen Species MH - Tissue Scaffolds/chemistry PMC - PMC9036007 OTO - NOTNLM OT - ROS scavenging OT - antioxidant defense OT - arthritis therapy OT - bioceramic scaffolds OT - osteochondral regeneration COIS- The authors declare no conflict of interest. EDAT- 2022/02/20 06:00 MHDA- 2022/04/27 06:00 PMCR- 2022/02/19 CRDT- 2022/02/19 05:33 PHST- 2021/12/09 00:00 [received] PHST- 2022/02/20 06:00 [pubmed] PHST- 2022/04/27 06:00 [medline] PHST- 2022/02/19 05:33 [entrez] PHST- 2022/02/19 00:00 [pmc-release] AID - ADVS3637 [pii] AID - 10.1002/advs.202105727 [doi] PST - ppublish SO - Adv Sci (Weinh). 2022 Apr;9(12):e2105727. doi: 10.1002/advs.202105727. Epub 2022 Feb 19.