PMID- 35182698
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20221115
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 488
DP  - 2022 Apr 15
TI  - Decreased Brain GABA Levels in Patients with Migraine Without Aura: An 
      Exploratory Proton Magnetic Resonance Spectroscopy Study.
PG  - 10-19
LID - S0306-4522(22)00064-1 [pii]
LID - 10.1016/j.neuroscience.2022.02.010 [doi]
AB  - Increasing neurophysiological studies had revealed that regional 
      excitation-inhibition imbalance in the brain played a key role in the 
      pathogenesis of migraine. This study aimed to explore the alterations in 
      gamma-aminobutyric acid (GABA) and glutamate/glutamine complex (Glx) levels in 
      the anterior cingulate gyrus (ACC) and medial prefrontal lobe (mPFC) of patients 
      with migraine without aura (MWoA) and investigate the correlation between 
      neurotransmitter levels and clinical indicators. A total of 28 patients with MWoA 
      and 28 sex-, age-, and education level-matched healthy controls (HCs) underwent 
      single-voxel proton magnetic resonance spectroscopy scanning at 3.0 Tesla. 
      MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) sequence was performed 
      to acquire the spectral data of GABA and Glx in the ACC and mPFC. The clinical 
      indicators and anxiety-depression states of all participants were assessed. The 
      acquired GABA signal contained the overlapping signals of macromolecules and 
      homocarnosine, hence expressed as GABA+. The creatine (Cr) signal was applied as 
      an endogenous reference. We observed that GABA+/Cr levels were significantly 
      lower in ACC and mPFC of patients with MWoA than of HCs, with no significant 
      difference in Glx levels. Negative correlations between GABA+/Cr levels and 
      attack frequency were found in the ACC and mPFC regions of patients. These 
      results suggested that there might be a close relationship between ACC and mPFC 
      GABAergic neurons abnormalities and the pathophysiological mechanisms of MWoA. It 
      might be beneficial to targeted treatment for patients with MWoA.
CI  - Copyright (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wu, Xiaojuan
AU  - Wu X
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China.
FAU - Han, Shuting
AU  - Han S
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China.
FAU - Dai, Hui
AU  - Dai H
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China.
FAU - Wu, Peng
AU  - Wu P
AD  - Philips Healthcare, Shanghai 200072, China.
FAU - Zhao, Hongru
AU  - Zhao H
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China. Electronic 
      address: tiantan11@163.com.
FAU - Jin, Xiaohong
AU  - Jin X
AD  - Department of Pain Management, The First Affiliated Hospital of Soochow 
      University, No. 899 Pinghai Road, Suzhou City, Jiangsu Province 215000, China. 
      Electronic address: jinxiaohong@suda.edu.cn.
FAU - Li, Yonggang
AU  - Li Y
AD  - Department of Radiology, The First Affiliated Hospital of Soochow University, 
      No.188, Shizi Road, Suzhou City, Jiangsu Province 215000, China. Electronic 
      address: liyonggang224@163.com.
LA  - eng
GR  - P41 EB031771/EB/NIBIB NIH HHS/United States
GR  - R01 EB016089/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220217
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0RH81L854J (Glutamine)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Creatine
MH  - Glutamic Acid
MH  - Glutamine
MH  - Gyrus Cinguli/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy/methods
MH  - *Migraine without Aura/diagnostic imaging
MH  - Proton Magnetic Resonance Spectroscopy
MH  - gamma-Aminobutyric Acid
PMC - PMC9652612
MID - NIHMS1846575
OTO - NOTNLM
OT  - (1)H-MRS
OT  - MEGA-PRESS
OT  - migraine without aura
OT  - neurotransmitter
COIS- DECLARATIONS OF INTEREST None.
EDAT- 2022/02/20 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/11/12
CRDT- 2022/02/19 20:09
PHST- 2021/08/29 00:00 [received]
PHST- 2022/02/09 00:00 [revised]
PHST- 2022/02/10 00:00 [accepted]
PHST- 2022/02/20 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/02/19 20:09 [entrez]
PHST- 2022/11/12 00:00 [pmc-release]
AID - S0306-4522(22)00064-1 [pii]
AID - 10.1016/j.neuroscience.2022.02.010 [doi]
PST - ppublish
SO  - Neuroscience. 2022 Apr 15;488:10-19. doi: 10.1016/j.neuroscience.2022.02.010. 
      Epub 2022 Feb 17.