PMID- 35183346
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20240202
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Print)
IS  - 0007-0912 (Linking)
VI  - 130
IP  - 2
DP  - 2023 Feb
TI  - The posterior dominant rhythm: an electroencephalographic biomarker for cognitive 
      recovery after general anaesthesia.
PG  - e233-e242
LID - S0007-0912(22)00028-9 [pii]
LID - 10.1016/j.bja.2022.01.019 [doi]
AB  - BACKGROUND: The posterior dominant rhythm (PDR) was the first oscillatory pattern 
      noted in the EEG. Evoked by wakeful eyelid closure, these oscillations dissipate 
      over seconds during loss of arousal. The peak frequency of the PDR maintains 
      stability over years, suggesting utility as a state biomarker in the surveillance 
      of acute cognitive impairments. This EEG signature has not been systematically 
      investigated for tracking cognitive dysfunction after anaesthetic-induced loss of 
      consciousness. METHODS: This substudy of Reconstructing Consciousness and 
      Cognition (NCT01911195) investigated the PDR and cognitive function in 60 adult 
      volunteers randomised to either 3 h of isoflurane general anaesthesia or resting 
      wakefulness. Serial measurements of EEG power and cognitive task performance were 
      assessed relative to pre-intervention baseline. Mixed-effects models allowed 
      quantification of PDR and neurocognitive trajectories after return of 
      responsiveness (ROR). RESULTS: Individuals in the control group showed stability 
      in the PDR peak frequency over several hours (median difference/inter-quartile 
      range [IQR] of 0.02/0.20 Hz, P=0.39). After isoflurane general anaesthesia, the 
      PDR peak frequency was initially reduced at ROR (median difference/IQR of 
      0.88/0.65 Hz, P<0.001). PDR peak frequency recovered at a rate of 0.20 Hz h(-1). 
      After ROR, the PDR peak frequency correlated with reaction time and accuracy on 
      multiple cognitive tasks (P<0.001). CONCLUSION: The temporal trajectory of the 
      PDR peak frequency could be a useful perioperative marker for tracking cognitive 
      dysfunction on the order of hours after surgery, particularly for cognitive 
      domains of working memory, visuomotor speed, and executive function. CLINICAL 
      TRIAL REGISTRATION: NCT01911195.
CI  - Copyright (c) 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Labonte, Alyssa K
AU  - Labonte AK
AD  - Department of Anesthesiology, Washington University School of Medicine in St. 
      Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, 
      Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
FAU - Kafashan, MohammadMehdi
AU  - Kafashan M
AD  - Department of Anesthesiology, Washington University School of Medicine in St. 
      Louis, St. Louis, MO, USA; Center on Biological Rhythms and Sleep, Washington 
      University School of Medicine in St. Louis, Missouri.
FAU - Huels, Emma R
AU  - Huels ER
AD  - Department of Anesthesiology, Washington University School of Medicine in St. 
      Louis, St. Louis, MO, USA; Department of Anesthesiology, Center for Consciousness 
      Science and Neuroscience Graduate Program, University of Michigan Medical School, 
      Ann Arbor, MI, USA.
FAU - Blain-Moraes, Stefanie
AU  - Blain-Moraes S
AD  - School of Physical and Occupational Therapy, McGill University, Montreal, QC, 
      Canada.
FAU - Basner, Mathias
AU  - Basner M
AD  - Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 
      Philadelphia, PA, USA.
FAU - Kelz, Max B
AU  - Kelz MB
AD  - Department of Anesthesiology and Critical Care, University of Pennsylvania 
      Perelman School of Medicine, Philadelphia, PA, USA.
FAU - Mashour, George A
AU  - Mashour GA
AD  - Department of Anesthesiology, Center for Consciousness Science and Neuroscience 
      Graduate Program, University of Michigan Medical School, Ann Arbor, MI, USA.
FAU - Avidan, Michael S
AU  - Avidan MS
AD  - Department of Anesthesiology, Washington University School of Medicine in St. 
      Louis, St. Louis, MO, USA; Center on Biological Rhythms and Sleep, Washington 
      University School of Medicine in St. Louis, Missouri; Department of Surgery, 
      Division of Cardiothoracic Surgery, Washington University School of Medicine in 
      St. Louis, St. Louis, MO, USA; Department of Psychiatry, Washington University 
      School of Medicine in St. Louis, St. Louis, MO, USA.
FAU - Palanca, Ben Julian A
AU  - Palanca BJA
AD  - Department of Anesthesiology, Washington University School of Medicine in St. 
      Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, 
      Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Center 
      on Biological Rhythms and Sleep, Washington University School of Medicine in St. 
      Louis, Missouri; Department of Psychiatry, Washington University School of 
      Medicine in St. Louis, St. Louis, MO, USA; Department of Biomedical Engineering, 
      Washington University in St. Louis, St. Louis, MO, USA. Electronic address: 
      palancab@wustl.edu.
CN  - ReCCognition Study Group
LA  - eng
SI  - ClinicalTrials.gov/NCT01911195
GR  - R01 AG057901/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20220217
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - CYS9AKD70P (Isoflurane)
RN  - 0 (Anesthetics)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Isoflurane/pharmacology
MH  - Electroencephalography
MH  - Anesthesia, General
MH  - *Anesthetics/pharmacology
MH  - Cognition
MH  - Alpha Rhythm
PMC - PMC9900730
OTO - NOTNLM
OT  - alpha oscillations
OT  - anaesthesia
OT  - biomarker
OT  - cognitive function
OT  - electroencephalography
OT  - posterior dominant rhythm
FIR - Muench, Maxwell
IR  - Muench M
FIR - Tarnal, Vijay
IR  - Tarnal V
FIR - Vanini, Giancarlo
IR  - Vanini G
FIR - Ochroch, E Andrew
IR  - Ochroch EA
FIR - Hogg, Rosemary
IR  - Hogg R
FIR - Schwarz, Marlon
IR  - Schwarz M
FIR - Janke, Ellen
IR  - Janke E
FIR - Golmirzaie, Goodarz
IR  - Golmirzaie G
FIR - Picton, Paul
IR  - Picton P
FIR - McKinstry-Wu, Andrew R
IR  - McKinstry-Wu AR
EDAT- 2022/02/21 06:00
MHDA- 2023/01/24 06:00
PMCR- 2024/02/01
CRDT- 2022/02/20 20:28
PHST- 2021/11/16 00:00 [received]
PHST- 2021/12/22 00:00 [revised]
PHST- 2022/01/09 00:00 [accepted]
PHST- 2022/02/21 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
PHST- 2022/02/20 20:28 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - S0007-0912(22)00028-9 [pii]
AID - 10.1016/j.bja.2022.01.019 [doi]
PST - ppublish
SO  - Br J Anaesth. 2023 Feb;130(2):e233-e242. doi: 10.1016/j.bja.2022.01.019. Epub 
      2022 Feb 17.