PMID- 35183823
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220531
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 152
DP  - 2022 Apr
TI  - IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental 
      autoimmune myocarditis.
PG  - 155823
LID - S1043-4666(22)00032-1 [pii]
LID - 10.1016/j.cyto.2022.155823 [doi]
AB  - Myocarditis is a kind of myocardial inflammatory infiltration disease. Many 
      interventions are not effective in the treatment of myocarditis because the 
      mechanism of myocarditis has not been elucidated. Previous studies have found 
      that interleukin-17 (IL-17) could stimulate the expression of monocyte chemokine 
      protein 1 (MCP-1) and mediate myocardial inflammatory infiltration. This study 
      aimed to explore the role of Act1/TRAF6/TAK1 cascade in IL-17-induced MCP-1 
      expression based on a well-designed experimental autoimmune myocarditis (EAM) 
      model. It was found that IL-17 could stimulate the expression of MCP-1 by 
      activating Act1/TRAF6/TAK1 cascade in EAM. The expression of Act1, TRAF6 and TAK1 
      followed downregulation by the application of IL-17 antibody. Additionally, 
      myocardial inflammatory cell infiltration was observably alleviated by 
      interfering TAK1 with TAK1 siRNA, and both MCP-1 mRNA and protein expression 
      followed downregulation. This study suggested that IL-17 could activate the 
      Act1/TRAF6/TAK1 pathway to upregulate MCP-1 expression in the EAM, and will offer 
      a new perspective for the study on the mechanism of myocarditis.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Huang, Xiao
AU  - Huang X
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, People's Republic of China; Key Clinical Laboratory 
      of Henan Province, Zhengzhou 450052, People's Republic of China.
FAU - Li, Zhuolun
AU  - Li Z
AD  - Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou 450052, People's Republic of China; Henan Key Laboratory of Precision 
      Clinical Pharmacy, Zhengzhou 450052, People's Republic of China.
FAU - Shen, Xinhe
AU  - Shen X
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, People's Republic of China; Key Clinical Laboratory 
      of Henan Province, Zhengzhou 450052, People's Republic of China.
FAU - Nie, Na
AU  - Nie N
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, People's Republic of China; Key Clinical Laboratory 
      of Henan Province, Zhengzhou 450052, People's Republic of China.
FAU - Shen, Yan
AU  - Shen Y
AD  - Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou 450052, People's Republic of China; Key Clinical Laboratory 
      of Henan Province, Zhengzhou 450052, People's Republic of China. Electronic 
      address: shenyan62687@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220217
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (ACT1 protein)
RN  - 0 (Chemokines)
RN  - 0 (Connexin 43)
RN  - 0 (Interleukin-17)
RN  - 0 (Peptide Fragments)
RN  - 0 (TNF Receptor-Associated Factor 6)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
RN  - EC 2.7.11.25 (MAP kinase kinase kinase 7)
SB  - IM
EIN - Cytokine. 2022 Jun;154:155879. PMID: 35413623
MH  - *Autoimmune Diseases/genetics
MH  - Chemokines/metabolism
MH  - Connexin 43/metabolism
MH  - Humans
MH  - Interleukin-17/metabolism
MH  - MAP Kinase Kinase Kinases/metabolism
MH  - Monocytes/metabolism
MH  - *Myocarditis/genetics
MH  - Peptide Fragments/metabolism
MH  - TNF Receptor-Associated Factor 6/metabolism
OTO - NOTNLM
OT  - Act1/TRAF6/TAK1 cascade
OT  - Experimental autoimmune myocarditis
OT  - Interleukin-17
OT  - Monocyte chemokine protein 1
EDAT- 2022/02/21 06:00
MHDA- 2022/04/15 06:00
CRDT- 2022/02/20 20:32
PHST- 2021/11/28 00:00 [received]
PHST- 2022/01/25 00:00 [revised]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/21 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/02/20 20:32 [entrez]
AID - S1043-4666(22)00032-1 [pii]
AID - 10.1016/j.cyto.2022.155823 [doi]
PST - ppublish
SO  - Cytokine. 2022 Apr;152:155823. doi: 10.1016/j.cyto.2022.155823. Epub 2022 Feb 17.