PMID- 35184022
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220428
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 144
DP  - 2022 Apr
TI  - The role of endoplasmic reticulum stress in the MHC class I antigen presentation 
      pathway of dendritic cells.
PG  - 44-48
LID - S0161-5890(22)00028-1 [pii]
LID - 10.1016/j.molimm.2022.02.007 [doi]
AB  - Dendritic cells (DCs) have the unique capacity to link innate to adaptive 
      immunity. While most cells that express major histocompatibility (MHC) molecules 
      are able to present antigens to activated T cells, DCs possess the means for 
      presenting antigens to naive T cells, and, as such, are able to instruct T cells 
      to initiate immune response. There are two cascades of events necessary for DCs 
      to start their instructive function. First, DCs enzymatically process proteins to 
      make T cells recognize an antigen as unique peptide-MHC complexes. Second, DCs 
      provide secretory cytokines and co-stimulatory functions for T cells to respond 
      to this antigen. Thus, the compartments for protein degradation and for protein 
      synthesis are central to DC function. The endoplasmic reticulum (ER), a vast 
      network of membranes and vesicles, connects these compartments and helps modulate 
      DC-specific performance, such as antigen capture and presentation. However, while 
      the health of ER appears relevant for DC function, the intersection between ER 
      stress and antigen presentation remains to be explored.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Manoury, Benedicte
AU  - Manoury B
AD  - Institut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, Faculte de medecine 
      Necker, Universite de Paris, 156-160 rue de Vaugirard, 75015 Paris, France. 
      Electronic address: benedicte.manoury@inserm.fr.
FAU - Maisonneuve, Lucie
AU  - Maisonneuve L
AD  - Institut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, Faculte de medecine 
      Necker, Universite de Paris, 156-160 rue de Vaugirard, 75015 Paris, France. 
      Electronic address: lucie.maisonneuve@inserm.fr.
FAU - Podsypanina, Katrina
AU  - Podsypanina K
AD  - Institut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, Faculte de medecine 
      Necker, Universite de Paris, 156-160 rue de Vaugirard, 75015 Paris, France. 
      Electronic address: katrina.podsypanina@inserm.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220217
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Antigens)
SB  - IM
MH  - *Antigen Presentation
MH  - Antigens
MH  - Dendritic Cells
MH  - *Endoplasmic Reticulum Stress
MH  - Histocompatibility
OTO - NOTNLM
OT  - Dendritic cells
OT  - Endoplasmic reticulum stress
OT  - IRE1alpha
OT  - MHCI antigen presentation
EDAT- 2022/02/21 06:00
MHDA- 2022/04/29 06:00
CRDT- 2022/02/20 20:37
PHST- 2021/07/22 00:00 [received]
PHST- 2021/12/21 00:00 [revised]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/02/21 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2022/02/20 20:37 [entrez]
AID - S0161-5890(22)00028-1 [pii]
AID - 10.1016/j.molimm.2022.02.007 [doi]
PST - ppublish
SO  - Mol Immunol. 2022 Apr;144:44-48. doi: 10.1016/j.molimm.2022.02.007. Epub 2022 Feb 
      17.