PMID- 35186015
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220223
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 12
DP  - 2021
TI  - Independent Evolution of the MYB Family in Brown Algae.
PG  - 811993
LID - 10.3389/fgene.2021.811993 [doi]
LID - 811993
AB  - Myeloblastosis (MYB) proteins represent one of the largest families of eukaryotic 
      transcription factors and regulate important processes in growth and development. 
      Studies on MYBs have mainly focused on animals and plants; however, comprehensive 
      analysis across other supergroups such as SAR (stramenopiles, alveolates, and 
      rhizarians) is lacking. This study characterized the structure, evolution, and 
      expression of MYBs in four brown algae, which comprise the biggest multicellular 
      lineage of SAR. Subfamily 1R-MYB comprised heterogeneous proteins, with fewer 
      conserved motifs found outside the MYB domain. Unlike the SHAQKY subgroup of 
      plant 1R-MYB, THAQKY comprised the largest subgroup of brown algal 1R-MYBs. 
      Unlike the expansion of 2R-MYBs in plants, brown algae harbored more 3R-MYBs than 
      2R-MYBs. At least ten 2R-MYBs, fifteen 3R-MYBs, and one 6R-MYB orthologs existed 
      in the common ancestor of brown algae. Phylogenetic analysis showed that brown 
      algal MYBs had ancient origins and a diverged evolution. They showed strong 
      affinity with stramenopile species, while not with red algae, green algae, or 
      animals, suggesting that brown algal MYBs did not come from the secondary 
      endosymbiosis of red and green plastids. Sequence comparison among all repeats of 
      the three types of MYB subfamilies revealed that the repeat of 1R-MYBs showed 
      higher sequence identity with the R3 of 2R-MYBs and 3R-MYBs, which supports the 
      idea that 1R-MYB was derived from loss of the first and second repeats of the 
      ancestor MYB. Compared with other species of SAR, brown algal MYB proteins 
      exhibited a higher proportion of intrinsic disordered regions, which might 
      contribute to multicellular evolution. Expression analysis showed that many MYB 
      genes are responsive to different stress conditions and developmental stages. The 
      evolution and expression analyses provided a comprehensive analysis of the 
      phylogeny and functions of MYBs in brown algae.
CI  - Copyright (c) 2022 Zeng, Liu, Chu, Niu, Wang, Markov and Teng.
FAU - Zeng, Qiangcheng
AU  - Zeng Q
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
FAU - Liu, Hanyu
AU  - Liu H
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
FAU - Chu, Xiaonan
AU  - Chu X
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
FAU - Niu, Yonggang
AU  - Niu Y
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
FAU - Wang, Caili
AU  - Wang C
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
FAU - Markov, Gabriel V
AU  - Markov GV
AD  - Sorbonne Universite, CNRS, Integrative Biology of Marine Models (LBI2M), Station 
      Biologique de Roscoff (SBR), Roscoff, France.
FAU - Teng, Linhong
AU  - Teng L
AD  - College of Life Sciences, Dezhou University, Dezhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220204
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC8854648
OTO - NOTNLM
OT  - MYB
OT  - brown algae
OT  - evolution
OT  - gene family
OT  - transcription factor
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/22 06:00
MHDA- 2022/02/22 06:01
PMCR- 2022/02/04
CRDT- 2022/02/21 06:01
PHST- 2021/11/09 00:00 [received]
PHST- 2021/12/27 00:00 [accepted]
PHST- 2022/02/21 06:01 [entrez]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/02/22 06:01 [medline]
PHST- 2022/02/04 00:00 [pmc-release]
AID - 811993 [pii]
AID - 10.3389/fgene.2021.811993 [doi]
PST - epublish
SO  - Front Genet. 2022 Feb 4;12:811993. doi: 10.3389/fgene.2021.811993. eCollection 
      2021.