PMID- 35186289
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220223
IS  - 2049-9361 (Print)
IS  - 2049-937X (Electronic)
IS  - 2049-9361 (Linking)
VI  - 9
DP  - 2022 Jan-Dec
TI  - Children living with HIV: a narrative review of recent advances in pediatric HIV 
      research and their implications for clinical practice.
PG  - 20499361221077544
LID - 10.1177/20499361221077544 [doi]
LID - 20499361221077544
AB  - Despite the great strides that have been made in prevention of mother to child 
      transmission (PMTCT), children continue to acquire HIV. The reduction in 
      transmission is variable, for example in Africa, great gains have been made in 
      Eastern and Southern Africa, but critical gaps remain in West and Central Africa. 
      These gaps are also observed in the treatment of children living with HIV. 
      Although there is increased access to lifesaving antiretroviral therapy (ART), 
      management of pediatric HIV infection continues to be a challenge to clinicians 
      in low-income countries where the disease burden is disproportionately high. On 
      the contrary, recent advances in ART drug types and formulations provide great 
      hope. In this narrative review, we present key updates in HIV care and promising 
      ART research among children and adolescents living with HIV. We particularly 
      highlight the dolutegravir (DTG) research which informed the change of the World 
      Health Organization (WHO) ART guidelines in this age group. Significant gaps 
      remain around management of children presenting with advanced disease to minimize 
      mortality and in the long-term care and treatment of adolescents living with HIV. 
      Research to address these sensitive areas is crucial for the realization of 
      global, regional, and national pediatric HIV targets.
CI  - (c) The Author(s), 2022.
FAU - Nalwanga, Damalie
AU  - Nalwanga D
AUID- ORCID: 0000-0002-1862-8109
AD  - Department of Pediatrics and Child Health, Makerere University Lung Institute, P. 
      O. Box 7072 Kampala, 256 Uganda.
FAU - Musiime, Victor
AU  - Musiime V
AD  - Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda; 
      Joint Clinical Research Centre, Kampala, Uganda.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220216
PL  - England
TA  - Ther Adv Infect Dis
JT  - Therapeutic advances in infectious disease
JID - 101606715
PMC - PMC8855388
OTO - NOTNLM
OT  - HIV infection in children
OT  - PMTCT
OT  - antiretroviral therapy
COIS- Conflict of interest statement: The authors declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2022/02/22 06:00
MHDA- 2022/02/22 06:01
PMCR- 2022/02/16
CRDT- 2022/02/21 06:03
PHST- 2021/10/01 00:00 [received]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/02/21 06:03 [entrez]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/02/22 06:01 [medline]
PHST- 2022/02/16 00:00 [pmc-release]
AID - 10.1177_20499361221077544 [pii]
AID - 10.1177/20499361221077544 [doi]
PST - epublish
SO  - Ther Adv Infect Dis. 2022 Feb 16;9:20499361221077544. doi: 
      10.1177/20499361221077544. eCollection 2022 Jan-Dec.