PMID- 35187125
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Epicardial Adipose Tissue and Postoperative Atrial Fibrillation.
PG  - 810334
LID - 10.3389/fcvm.2022.810334 [doi]
LID - 810334
AB  - BACKGROUND: Atrial fibrillation (AF) often occurs after cardiac surgery and is 
      associated with increased risk of stroke and mortality. Prior studies support the 
      important role of inflammation in the pathogenesis of postoperative atrial 
      fibrillation (POAF). It is known that an increased volume and a pro-inflammatory 
      phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in 
      non surgical context. In the present study, we aim to evaluate whether also POAF 
      occurrence may be triggered by an increased production of inflammatory mediators 
      from EAT. METHODS: The study population was composed of 105 patients, with no 
      history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After 
      clinical evaluation, all patients performed an echocardiographic study including 
      the measurement of EAT thickness. Serum samples and EAT biopsies were collected 
      before surgery. Levels of 10 inflammatory cytokines were measured in serum and 
      EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days. 
      RESULTS: Forty-four patients (41.3%) developed POAF. As regard to cardiovascular 
      therapy, only statin use was significantly lower in POAF patients (65.1% vs. 
      84.7%; p-0.032). Levels of Monocyte Chemoattractant Protein-1 (MCP-1), in both 
      serum and EAT, were significantly higher in POAF patients (130.1 pg/ml vs. 68.7 
      pg/ml; p = <0.001; 322.4 pg/ml vs. 153.4 pg/ml; p = 0.028 respectively). EAT 
      levels of IL-6 were significantly increased in POAF patients compared to those in 
      sinus rhythm (SR) (126.3 pg/ml vs. 23 pg/ml; p = <0.005). CONCLUSION: Higher EAT 
      levels of IL-6 and MCP-1 are significantly associated with the occurrence of 
      POAF. Statin therapy seems to play a role in preventing POAF. These results might 
      pave the way for a targeted use of these drugs in the perioperative period.
CI  - Copyright (c) 2022 Petraglia, Conte, Comentale, Cabaro, Campana, Russo, Amaranto, 
      Bruzzese, Formisano, Pilato, Ferrara, Leosco and Parisi.
FAU - Petraglia, Laura
AU  - Petraglia L
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Conte, Maddalena
AU  - Conte M
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
AD  - Clinica San Michele, Maddaloni, Italy.
FAU - Comentale, Giuseppe
AU  - Comentale G
AD  - Department of Advanced Biomedical Sciences, University of Naples Federico II, 
      Naples, Italy.
FAU - Cabaro, Serena
AU  - Cabaro S
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Campana, Pasquale
AU  - Campana P
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Russo, Carmela
AU  - Russo C
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Amaranto, Ilaria
AU  - Amaranto I
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Bruzzese, Dario
AU  - Bruzzese D
AD  - Department of Public Health, University of Naples Federico II, Naples, Italy.
FAU - Formisano, Pietro
AU  - Formisano P
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Pilato, Emanuele
AU  - Pilato E
AD  - Department of Advanced Biomedical Sciences, University of Naples Federico II, 
      Naples, Italy.
FAU - Ferrara, Nicola
AU  - Ferrara N
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Leosco, Dario
AU  - Leosco D
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
FAU - Parisi, Valentina
AU  - Parisi V
AD  - Department of Translational Medicine, University of Naples Federico II, Naples, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20220204
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8854347
OTO - NOTNLM
OT  - Monocyte Chemoattractant Protein-1
OT  - epicardial adipose tissue
OT  - inflammation
OT  - interleukin-6
OT  - postoperative atrial fibrillation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The reviewer PC declared a shared affiliation, with several 
      of the authors to the handling editor at the time of the review.
EDAT- 2022/02/22 06:00
MHDA- 2022/02/22 06:01
PMCR- 2022/01/01
CRDT- 2022/02/21 06:05
PHST- 2021/11/06 00:00 [received]
PHST- 2022/01/06 00:00 [accepted]
PHST- 2022/02/21 06:05 [entrez]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/02/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.810334 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Feb 4;9:810334. doi: 10.3389/fcvm.2022.810334. 
      eCollection 2022.