PMID- 35187144
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220223
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 9
DP  - 2022
TI  - Efficacy of the Synergy Between Live-Attenuated and Inactivated PRRSV Vaccines 
      Against a NADC30-Like Strain of Porcine Reproductive and Respiratory Syndrome 
      Virus in 4-Week Piglets.
PG  - 812040
LID - 10.3389/fvets.2022.812040 [doi]
LID - 812040
AB  - The NADC30-like strain of porcine reproductive and respiratory syndrome virus 
      (PRRSV) is a novel strain responsible for substantial economic losses to swine 
      production in China. This study evaluated the cross-protective efficacy of the 
      synergy between live-attenuated and inactivated PRRSV vaccines compared with a 
      single vaccination with PRRS modified-live virus (MLV) vaccine against challenge 
      with NADC30-like strain, v2016/ZJ/09-03. A total of 45 PRRSV free pigs were 
      randomly divided into five groups: (1) strict control (SC); (2) positive control 
      (PC); (3) single MLV dose (M1); (4) primed intramuscularly with MLV and boosted 
      with killed vaccine 3 weeks later (MK1); and (5) intramuscular prime MLV boosted 
      subcutaneously with killed vaccine B 3 weeks later (MK2). Serological tests in MK 
      groups revealed no differences in both anti-N and anti-GP protein antibodies 
      compared with M1 group, and failed to provide further protection against clinical 
      signs, virus shedding, and gross lesions. However, the viremic titer, gross lung 
      lesions, and average daily weight gain were significantly improved in the MLV 
      vaccinated groups, suggesting that MLV provides substantial cross-protection 
      against the NADC30-like virus. Thus, as a booster, the killed vaccine confers 
      minimal additional protection in NADC30-like infected piglets.
CI  - Copyright (c) 2022 Li, Liu, Chen, Qian, Hu, Fang, Sun, Zhang, Huang, Zhang and 
      Huang.
FAU - Li, Chaosi
AU  - Li C
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Liu, Zhicheng
AU  - Liu Z
AD  - Maoming Branch Center of Guangdong Laboratory for LingNan Modern Agricultural 
      Science and Technology, Key Laboratory of Livestock Disease Prevention of 
      Guangdong Province, Scientific Observation and Experiment Station of Veterinary 
      Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture 
      and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural 
      Sciences, Guangzhou, China.
FAU - Chen, Kai
AU  - Chen K
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Qian, Jie
AU  - Qian J
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Hu, Yulong
AU  - Hu Y
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Fang, Shuhe
AU  - Fang S
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Sun, Zhi
AU  - Sun Z
AD  - Asian Veterinary Research and Development Center, Boehringer Ingelheim (China) 
      Investment Co., Ltd., Shanghai, China.
FAU - Zhang, Chunhong
AU  - Zhang C
AD  - Maoming Branch Center of Guangdong Laboratory for LingNan Modern Agricultural 
      Science and Technology, Key Laboratory of Livestock Disease Prevention of 
      Guangdong Province, Scientific Observation and Experiment Station of Veterinary 
      Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture 
      and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural 
      Sciences, Guangzhou, China.
FAU - Huang, Lv
AU  - Huang L
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
FAU - Zhang, Jianfeng
AU  - Zhang J
AD  - Maoming Branch Center of Guangdong Laboratory for LingNan Modern Agricultural 
      Science and Technology, Key Laboratory of Livestock Disease Prevention of 
      Guangdong Province, Scientific Observation and Experiment Station of Veterinary 
      Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture 
      and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural 
      Sciences, Guangzhou, China.
FAU - Huang, Nian
AU  - Huang N
AD  - Boehringer Ingelheim Animal Health (Shanghai) Co. Ltd., Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20220202
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC8847452
OTO - NOTNLM
OT  - NADC30-like
OT  - heterologous-protection
OT  - inactivated vaccine
OT  - pathogenicity
OT  - porcine reproductive and respiratory syndrome virus
OT  - vaccination
COIS- CL, KC, JQ, YH, SF, LH, and NH were employed by Boehringer Ingelheim Animal 
      Health (Shanghai) Co. Ltd. ZS was employed by Boehringer Ingelheim (China) 
      Investment Co., Ltd. The remaining authors declare that the research was 
      conducted in the absence of any commercial or financial relationships that could 
      be construed as a potential conflict of interest.
EDAT- 2022/02/22 06:00
MHDA- 2022/02/22 06:01
PMCR- 2022/01/01
CRDT- 2022/02/21 06:05
PHST- 2021/11/11 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/02/21 06:05 [entrez]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/02/22 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2022.812040 [doi]
PST - epublish
SO  - Front Vet Sci. 2022 Feb 2;9:812040. doi: 10.3389/fvets.2022.812040. eCollection 
      2022.