PMID- 35187767
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220712
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 35
IP  - 5
DP  - 2022 May
TI  - Association between human leukocyte antigens and cutaneous adverse drug reactions 
      to antiepileptics and antibiotics in the Iranian population.
PG  - e15393
LID - 10.1111/dth.15393 [doi]
AB  - In this case-control study, class capital I, Ukrainian and capital I, Ukrainiancapital I, Ukrainian human leukocyte antigen (HLA) alleles 
      in Iranian patients with benign and severe cutaneous adverse drug reactions 
      (CADRs) due to aromatic anticonvulsants and antibiotics were evaluated. Patients 
      diagnosed with CADRs (based on clinical and laboratory findings) with a Naranjo 
      score of >/= 4 underwent blood sampling and HLA-DNA typing. The control group 
      comprised 90 healthy Iranian adults. Alleles with a frequency of more than two 
      were reported. Deviations from Hardy-Weinberg equilibrium were not observed. 
      Eighty patients with CADRs including 54 females and 26 males with a mean age of 
      41.49 +/- 16.08 years were enrolled in this study. The culprit drugs included 
      anticonvulsants (lamotrigine, carbamazepine, and phenytoin) and antibiotics 
      (ciprofloxacin and co-trimoxazole). The comparison of allele frequencies in the 
      Iranian healthy control group and the group with benign CADRs revealed that 
      HLA-Cw*04, and HLA-A*24 were significantly associated with lamotrigine-induced 
      maculopapular CADRs. Furthermore, HLA-B*51 showed a significant correlation with 
      carbamazepine-induced maculopapular CADRs. Significant associations were also 
      detected between ciprofloxacin-induced urticarial CADRs with HLA-B*40, and 
      HLA-DRB1*14. In the severe group, HLA-B*38 and HLA-DRB1*13 were significantly 
      associated with lamotrigine-induced Stevens-Johnson syndrome/toxic epidermal 
      necrolysis (SJS/TEN). Moreover, HLA-A*31 and HLA-Cw*04 were significantly 
      correlated with carbamazepine-induced drug reactions with eosinophilia and 
      systemic symptoms (DRESS). HLA-B*08 also showed a significant correlation with 
      ciprofloxacin-induced acute generalized exanthematous pustulosis (AGEP). In 
      conclusion, Lamotrigine-induced MPE was significantly correlated with HLA-Cw*04, 
      and HLA-A*24. Similarly, lamotrigine-induced SJS/TEN was significantly associated 
      with HLA-B*38 and HLA-DRB1*13. Additionally, HLA-A*31 was associated with DRESS 
      caused by carbamazepine. The most frequent CADR-inducing drugs were 
      anticonvulsants.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Mortazavi, Hossein
AU  - Mortazavi H
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
FAU - Rostami, Anahita
AU  - Rostami A
AUID- ORCID: 0000-0001-5049-3008
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
FAU - Firooz, Alireza
AU  - Firooz A
AUID- ORCID: 0000-0001-7274-4840
AD  - Center for Research & Training in Skin Diseases & Leprosy, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Esmaili, Nafiseh
AU  - Esmaili N
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
AD  - Autoimmune Bullous Diseases Research Center, Tehran University of Medical 
      Sciences, Razi Hospital, Tehran, Iran.
FAU - Ghiasi, Maryam
AU  - Ghiasi M
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
FAU - Lajevardi, Vahideh
AU  - Lajevardi V
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
AD  - Molecular Immunology Research Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Immunogenetic Laboratory, Department of Immunology, Faculty of Medicine, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Sheykhi, Iman
AU  - Sheykhi I
AD  - Industrial Engineering Department, Sharif University of Technology, Tehran, Iran.
FAU - Khamesipour, Ali
AU  - Khamesipour A
AD  - Center for Research & Training in Skin Diseases & Leprosy, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Akhdar, Marwa
AU  - Akhdar M
AUID- ORCID: 0000-0001-5800-810X
AD  - Department of Dermatology Tehran University of Medical Sciences, Razi Hospital, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220228
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 33CM23913M (Carbamazepine)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/adverse effects
MH  - *Anticonvulsants/adverse effects
MH  - Carbamazepine/adverse effects
MH  - Case-Control Studies
MH  - Ciprofloxacin/adverse effects
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Iran
MH  - Lamotrigine
MH  - Male
MH  - Middle Aged
MH  - *Stevens-Johnson Syndrome/etiology
OTO - NOTNLM
OT  - antibiotics
OT  - antiepileptics
OT  - culprit drug
OT  - cutaneous adverse drug reaction
OT  - human leukocyte antigen
EDAT- 2022/02/22 06:00
MHDA- 2022/05/07 06:00
CRDT- 2022/02/21 06:10
PHST- 2021/10/13 00:00 [revised]
PHST- 2021/01/01 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
PHST- 2022/02/21 06:10 [entrez]
AID - 10.1111/dth.15393 [doi]
PST - ppublish
SO  - Dermatol Ther. 2022 May;35(5):e15393. doi: 10.1111/dth.15393. Epub 2022 Feb 28.