PMID- 35189103
OWN - NLM
STAT- MEDLINE
DCOM- 20220506
LR  - 20220622
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 210
DP  - 2022 Jul
TI  - Prevalence of type 2 diabetes mellitus in relation to arsenic exposure and 
      metabolism in Mexican women.
PG  - 112948
LID - S0013-9351(22)00275-4 [pii]
LID - 10.1016/j.envres.2022.112948 [doi]
AB  - BACKGROUND: Experimental studies have shown the diabetogenic potential of 
      inorganic arsenic (iAs); however, the epidemiological evidence is still 
      inconclusive. This could be explained by differences in exposure, metabolism 
      efficiency, nutritional and genetic factors. OBJECTIVE: To evaluate the 
      association between type 2 diabetes mellitus (T2DM) prevalence with arsenic 
      exposure and metabolism, considering one-carbon metabolism nutrient intake and 
      arsenite methyltransferase (AS3MT) polymorphisms. METHODS: From healthy controls 
      of a case control study for female breast cancer in northern Mexico, 227 
      self-reported diabetic women were age-matched with 454 non-diabetics. 
      Participants were interviewed about dietary, sociodemographic and clinical 
      characteristics. Urinary iAs metabolites were determined by HPLC-ICP-MS, 
      methylation efficiency parameters were calculated, and AS3MT c.860 T > C and 
      c.529-56G > C genotypes were determined. Unconditional logistic regression models 
      were used to evaluate associations. RESULTS: Total arsenic in urine (TAs) ranged 
      from 0.73 to 248.12 mug/L with a median of 10.48 mug/L. In unadjusted analysis, TAs 
      (mug/g) was significantly higher in cases than controls, but not when expressed as 
      TAs (mug/L). Cases had significantly lower urinary monomethylarsonic acid 
      percentage (%MMA), first methylation ratio (FMR), creatinine, and choline and 
      selenium intakes. In multi-adjusted models and in women without HTA history T2DM 
      showed significant positive associations with %iAs and FMR, respectively, and a 
      significant negative association with %DMA. In participants with HTA history 
      there was a marginal positive association (p = 0.08) between T2DM and TAs 
      concentrations (mug/g) without other significant associations. CONCLUSIONS: Our 
      results support an association between T2DM prevalence and iAs metabolism but not 
      with urinary arsenic levels. However, elucidation of the interplay among iAs 
      metabolism, T2DM and HTA merit further studies.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Rangel-Moreno, Karla
AU  - Rangel-Moreno K
AD  - Instituto Nacional de Salud Publica, Av. Universidad 655, Col. Santa Maria 
      Ahuacatitlan, C.P. 62100, Cuernavaca, Morelos, Mexico.
FAU - Gamboa-Loira, Brenda
AU  - Gamboa-Loira B
AD  - Instituto Nacional de Salud Publica, Av. Universidad 655, Col. Santa Maria 
      Ahuacatitlan, C.P. 62100, Cuernavaca, Morelos, Mexico.
FAU - Lopez-Carrillo, Lizbeth
AU  - Lopez-Carrillo L
AD  - Instituto Nacional de Salud Publica, Av. Universidad 655, Col. Santa Maria 
      Ahuacatitlan, C.P. 62100, Cuernavaca, Morelos, Mexico.
FAU - Cebrian, Mariano E
AU  - Cebrian ME
AD  - Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados Del 
      Instituto Politecnico Nacional, Av. Instituto Politecnico Nacional 2508, Col. San 
      Pedro Zacatenco, Ciudad de Mexico, C.P. 07360, Mexico. Electronic address: 
      mcebrian@cinvestav.mx.
LA  - eng
PT  - Journal Article
DEP - 20220219
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Arsenicals)
RN  - EC 2.1.1.- (Methyltransferases)
RN  - EC 2.1.1.137 (AS3MT protein, human)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - *Arsenic/analysis
MH  - *Arsenicals/analysis
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Methyltransferases
MH  - Mexico/epidemiology
MH  - Prevalence
OTO - NOTNLM
OT  - Arsenic metabolism
OT  - Creatinine
OT  - Nutrients
OT  - Polymorphisms
OT  - Type 2 diabetes mellitus
EDAT- 2022/02/22 06:00
MHDA- 2022/05/07 06:00
CRDT- 2022/02/21 20:10
PHST- 2021/06/11 00:00 [received]
PHST- 2022/02/07 00:00 [revised]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/05/07 06:00 [medline]
PHST- 2022/02/21 20:10 [entrez]
AID - S0013-9351(22)00275-4 [pii]
AID - 10.1016/j.envres.2022.112948 [doi]
PST - ppublish
SO  - Environ Res. 2022 Jul;210:112948. doi: 10.1016/j.envres.2022.112948. Epub 2022 
      Feb 19.