PMID- 35189282
OWN - NLM
STAT- MEDLINE
DCOM- 20220524
LR  - 20231018
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 91
DP  - 2022 May-Jun
TI  - Impacts of a perinatal exposure to manganese coupled with maternal stress in 
      rats: Learning, memory and attentional function in exposed offspring.
PG  - 107077
LID - S0892-0362(22)00015-0 [pii]
LID - 10.1016/j.ntt.2022.107077 [doi]
AB  - The developmental effects of chemicals that co-occur in vulnerable populations 
      with elevated psychological stress are of increasing concern to the public. To 
      investigate these concerns, we developed a rodent model of co-occurring perinatal 
      manipulations and conducted a series of cognitive assessments in male and female 
      offspring. Manganese (Mn), a neurodevelopmental toxicant when exceeding 
      physiological requirements, was delivered in the drinking water (0, 2, or 4 mg 
      Mn/mL) of rats from gestational day (GD) 7 to postnatal day (PND) 22. A variable 
      perinatal stress paradigm was applied to half of the animals from GD13 to PND9. 
      Novel object recognition (NOR), Morris water maze (MWM), differential 
      reinforcement of low-rates procedure (DRL) and cued and uncued choice reaction 
      time (CRT) tests were used to assess cognitive functions in offspring. Mn 
      (4 mg/mL) and stress impaired NOR in adolescent males but facilitated NOR 
      performance in females. However, when stress and Mn were combined these effects 
      were attenuated in both sexes. During training for the DRL, Mn (2 mg/mL) 
      facilitated, while stress impaired, lever press learning in both sexes. Few 
      effects related to the treatments were found on DRL or MWM. During cued CRT, Mn 
      (2 and 4 mg/mL) and stress reduced accuracy in males, while stress and Mn 
      (2 mg/mL) increased anticipatory responding and slowed decision time in both 
      sexes. Stress combined with Mn (2 mg/mL) improved cued accuracy and decision 
      time, and Mn attenuated the effect of stress on anticipatory responding in both 
      sexes. Stress slowed female movement time but when combined with Mn (4 mg/mL) the 
      effect of stress was attenuated. During uncued CRT, except for decision time 
      (which replicated effects observed with the cued task), no other effects of Mn or 
      its combination with stress occurred. Females remained negatively affected by 
      stress in most uncued CRT performance measures, while stressed improved male 
      uncued accuracy. Taken together these data do not support increased cognitive 
      impairment produced by Mn when combined with stress. However, the effects of 
      perinatal stress alone, on these cognitive functions may hinder the detection of 
      effects due to chemical exposures and underscores the need to consider the 
      psychological health and wellbeing of the mother and her environment in risk 
      assessment for developmental neurotoxicity of chemicals.
CI  - Published by Elsevier Inc.
FAU - Oshiro, W M
AU  - Oshiro WM
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America. Electronic address: 
      oshiro.wendy@epa.gov.
FAU - McDaniel, K L
AU  - McDaniel KL
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
FAU - Beasley, T E
AU  - Beasley TE
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
FAU - Moser, V
AU  - Moser V
AD  - Retired, Office of Research and Development, U.S. Environmental Protection 
      Agency, Research Triangle Park, NC 27711, United States of America.
FAU - Herr, D W
AU  - Herr DW
AD  - Public Health & Integrated Toxicology Division, Center for Public Health and 
      Environmental Assessment, United States of America.
LA  - eng
GR  - EPA999999/ImEPA/Intramural EPA/United States
PT  - Journal Article
DEP - 20220218
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 42Z2K6ZL8P (Manganese)
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Attention
MH  - Female
MH  - Humans
MH  - Male
MH  - *Manganese/toxicity
MH  - Maze Learning
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Rats
MH  - Reaction Time
PMC - PMC10578066
MID - NIHMS1927448
OTO - NOTNLM
OT  - Attention
OT  - Cognitive function
OT  - Developmental neurotoxicity
OT  - Manganese
OT  - Memory
OT  - Perinatal stress
OT  - Rat
OT  - Reaction time
EDAT- 2022/02/22 06:00
MHDA- 2022/05/25 06:00
PMCR- 2023/10/16
CRDT- 2022/02/21 20:10
PHST- 2021/09/30 00:00 [received]
PHST- 2022/01/07 00:00 [revised]
PHST- 2022/02/15 00:00 [accepted]
PHST- 2022/02/22 06:00 [pubmed]
PHST- 2022/05/25 06:00 [medline]
PHST- 2022/02/21 20:10 [entrez]
PHST- 2023/10/16 00:00 [pmc-release]
AID - S0892-0362(22)00015-0 [pii]
AID - 10.1016/j.ntt.2022.107077 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2022 May-Jun;91:107077. doi: 10.1016/j.ntt.2022.107077. 
      Epub 2022 Feb 18.