PMID- 35193041 OWN - NLM STAT- MEDLINE DCOM- 20220428 LR - 20220428 IS - 1872-6976 (Electronic) IS - 0167-4943 (Linking) VI - 100 DP - 2022 May-Jun TI - Screening for deficits on intrinsic capacity domains and associated healthcare costs. PG - 104654 LID - S0167-4943(22)00035-8 [pii] LID - 10.1016/j.archger.2022.104654 [doi] AB - BACKGROUND/OBJECTIVE: Intrinsic capacity (IC) defined by the World Health Organization is divided into six domains (locomotion, psychological, vitality/nutrition, cognition, vision and hearing). The main objective of this study therefore is to explore the association between healthcare costs and IC domains deficits among older patients. PARTICIPANTS AND SETTING: This longitudinal secondary analysis was performed on data from the Multidomain Alzheimer Preventive Trial (MAPT), a 3-year randomized controlled trial with non-demented community-dwelling participants aged 70 years or over. METHODS: We used an adapted version of the ICOPE (Integrated Care for Older People) Step 1 to screen for the six operational IC domains deficits at three time-points: baseline, one year and two years. We performed bivariate and multivariate analyzes using generalized linear models and generalized estimating equation models to identify associations between healthcare cost and deficits on IC domains. RESULTS: We analyzed 693 patients (aged 75.2 +/- 4.22 years; 64% women (N = 442)). At baseline, among the included patients, 89% had at least one impairment in IC domains (N = 619). A deficit on visual capacity was associated with increased immediate healthcare costs (CR: 1.48; 95CI: [1.16-1.89]). Regarding persistent impairment of IC, locomotor (CR: 1.27; 95CI: [1.01-1.60], additional annual healthcare cost: euro1092 per patient) and psychological (CR: 1.28; 95CI: [1.03-1.59], additional annual healthcare cost: euro817 per patient) capacities were associated with increased healthcare costs. CONCLUSION: In conclusion, this study showed that some deficits on IC domains, as measured by simple screening tests and questions, can be associated with higher healthcare costs. CLINICALTRIALS: gov identifier: NCT00672685. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Pages, Arnaud AU - Pages A AD - Department of Pharmacy, Hopital Paule de Viguier, CHU de Toulouse, 330, avenue de Grande Bretagne - TSA 7003431059 Cedex 9, Toulouse, France; Gerontopole, Institute of Aging, CHU de Toulouse, INSPIRE Project, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. Electronic address: pages.ar@chu-toulouse.fr. FAU - Costa, Nadege AU - Costa N AD - CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France; Economic Evaluation Unit, Medical Information Department, CHU de Toulouse, Toulouse, France. FAU - Gonzalez-Bautista, Emmanuel AU - Gonzalez-Bautista E AD - Gerontopole, Institute of Aging, CHU de Toulouse, INSPIRE Project, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Mounie, Michael AU - Mounie M AD - CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France; Economic Evaluation Unit, Medical Information Department, CHU de Toulouse, Toulouse, France. FAU - Juillard-Condat, Blandine AU - Juillard-Condat B AD - Department of Pharmacy, Hopital Paule de Viguier, CHU de Toulouse, 330, avenue de Grande Bretagne - TSA 7003431059 Cedex 9, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Molinier, Laurent AU - Molinier L AD - CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France; Economic Evaluation Unit, Medical Information Department, CHU de Toulouse, Toulouse, France. FAU - Cestac, Philippe AU - Cestac P AD - Department of Pharmacy, Hopital Paule de Viguier, CHU de Toulouse, 330, avenue de Grande Bretagne - TSA 7003431059 Cedex 9, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Rolland, Yves AU - Rolland Y AD - Gerontopole, Institute of Aging, CHU de Toulouse, INSPIRE Project, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Vellas, Bruno AU - Vellas B AD - Gerontopole, Institute of Aging, CHU de Toulouse, INSPIRE Project, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. FAU - De Souto Barreto, Philipe AU - De Souto Barreto P AD - Gerontopole, Institute of Aging, CHU de Toulouse, INSPIRE Project, Toulouse, France; CERPOP, UMR 1295, Universite de Toulouse, Inserm, Universite Paul Sabatier, Toulouse, France. CN - MAPT/DSA Group LA - eng SI - ClinicalTrials.gov/NCT00672685 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20220207 PL - Netherlands TA - Arch Gerontol Geriatr JT - Archives of gerontology and geriatrics JID - 8214379 SB - IM MH - Aged MH - *Alzheimer Disease/diagnosis MH - Female MH - Health Care Costs MH - Humans MH - Independent Living MH - Male MH - Mass Screening MH - World Health Organization OTO - NOTNLM OT - Functional performance OT - Healthcare cost OT - Integrated care of older people OT - Intrinsic capacity OT - Screening EDAT- 2022/02/23 06:00 MHDA- 2022/04/29 06:00 CRDT- 2022/02/22 20:11 PHST- 2021/12/31 00:00 [received] PHST- 2022/02/01 00:00 [revised] PHST- 2022/02/06 00:00 [accepted] PHST- 2022/02/23 06:00 [pubmed] PHST- 2022/04/29 06:00 [medline] PHST- 2022/02/22 20:11 [entrez] AID - S0167-4943(22)00035-8 [pii] AID - 10.1016/j.archger.2022.104654 [doi] PST - ppublish SO - Arch Gerontol Geriatr. 2022 May-Jun;100:104654. doi: 10.1016/j.archger.2022.104654. Epub 2022 Feb 7.