PMID- 35196657
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20220826
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 183
IP  - 7
DP  - 2022
TI  - Correlation between Increased Monocyte Chemotactic Protein 1 Level and Lung 
      Function in Patients with Asthma.
PG  - 753-761
LID - 10.1159/000521946 [doi]
AB  - BACKGROUND: The altered expression of monocyte chemotactic protein 1 (MCP1) in 
      bronchoalveolar fluid was observed in patients and animal models of allergic 
      asthma. However, the correlation between induced sputum MCP1 level and asthma 
      clinical features remains poorly understood. OBJECTIVE: This study aims to 
      explore the relationship of MCP1 protein expression in induced sputum with Th2 
      inflammation and asthma clinical features. METHODS: MCP1 protein expression in 
      induced sputum and serum was detected by ELISA in patients with asthma, and its 
      correlation with Th2 inflammation and lung function was analyzed. The effect of 
      inhaled corticosteroids (ICSs) on MCP1 expression was also evaluated. RESULTS: 
      The MCP1 level in induced sputum (p = 0.0006) and serum (p = 0.0035) was markedly 
      increased and negatively correlated with forced expiratory volume in 1 s 
      (FEV1)/forced vital capacity (FVC)% (r = -0.3674, p = 0.0001) and PC-20 (r = 
      -0.5746, p < 0.0001) in patients with asthma. The area under the curve (AUC) of 
      MCP1 level receiver operating characteristic curve in induced sputum and serum 
      was 0.7134 (p = 0.0007) and 0.7589 (p = 0.0042), respectively. The patients with 
      asthma were grouped into four according to their induced sputum MCP1 level and 
      Th2 signature categories (Th2Hi MCP1Hi, Th2Hi MCP1Low, Th2Low MCP1Hi, and Th2Low 
      MCP1Low). The Th2Low MCP1Hi subgroup had the lowest FEV1/FVC% and histamine 
      concentration required to cause a 20% decline in FEV1. After 4 weeks of ICS 
      treatment, the MCP1 levels in induced sputum and serum were significantly 
      reduced. CONCLUSIONS: The MCP1 level in induced sputum and serum increased in 
      patients with asthma but decreased after ICS treatment. The Th2Low MCP1Hi 
      subgroup had the worst lung function and highest airway hyperresponsiveness. The 
      combination of MCP1 level in induced sputum and Th2 inflammation defines a new 
      phenotype that can be used to predict lung function and treatment response in 
      patients with asthma.
CI  - (c) 2022 S. Karger AG, Basel.
FAU - Zong, Weifeng
AU  - Zong W
AD  - Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Mo, Yuqing
AU  - Mo Y
AD  - Department of internal Medicine, Affiliated Cancer Hospital of Zhengzhou 
      University, Henan Cancer Hospital, Zhengzhou, China.
FAU - Liang, Yuxia
AU  - Liang Y
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Sun Yat-Sen University, Guangzhou, China.
AD  - Institute of Respiratory Diseases of Sun Yat-Sen University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220223
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - *Asthma/diagnosis/metabolism
MH  - *Chemokine CCL2/metabolism
MH  - Eosinophils/metabolism
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Inflammation/metabolism
MH  - *Lung/metabolism/physiopathology
MH  - Sputum
OTO - NOTNLM
OT  - Asthma
OT  - Induced sputum
OT  - Lung function
OT  - Monocyte chemotactic protein 1
EDAT- 2022/02/24 06:00
MHDA- 2022/07/08 06:00
CRDT- 2022/02/23 20:11
PHST- 2021/12/07 00:00 [received]
PHST- 2021/12/28 00:00 [accepted]
PHST- 2022/02/24 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/02/23 20:11 [entrez]
AID - 000521946 [pii]
AID - 10.1159/000521946 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2022;183(7):753-761. doi: 10.1159/000521946. Epub 2022 
      Feb 23.