PMID- 35197392
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20231216
IS  - 1347-3700 (Electronic)
IS  - 0386-7196 (Print)
IS  - 0386-7196 (Linking)
VI  - 47
IP  - 1
DP  - 2022
TI  - Ubiquitin-like 3 as a new protein-sorting factor for small extracellular 
      vesicles.
PG  - 1-18
LID - 10.1247/csf.21078 [doi]
AB  - Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in 
      eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 
      in cellular processes remained unknown. Recently, UBL3 was elucidated to be a 
      post-translational modification factor that promotes protein sorting to small 
      extracellular vesicles (sEVs). Proteins sorted into sEVs have been studied as 
      etiologies of sEV-related diseases. Also, there have been attempts to construct 
      drug delivery systems (DDSs) by loading proteins into sEVs. In this review, we 
      introduce the new concept that UBL3 has a critical role in the protein-sorting 
      system and compare structure conservation between UBL3 and other UBLs from an 
      evolutionary perspective. We conclude with future perspectives for the utility of 
      UBL3 in sEV-related diseases and DDS.Key words: UBL3, small extracellular 
      vesicles, protein sorting, ubiquitin-like protein, post-translational 
      modification.
FAU - Takanashi, Yusuke
AU  - Takanashi Y
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Kahyo, Tomoaki
AU  - Kahyo T
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
FAU - Kamamoto, Sae
AU  - Kamamoto S
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
FAU - Zhang, Hengsen
AU  - Zhang H
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
FAU - Ping, Yashuang
AU  - Ping Y
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
FAU - Mizuno, Kiyomichi
AU  - Mizuno K
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Kawase, Akikazu
AU  - Kawase A
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Koizumi, Kei
AU  - Koizumi K
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Satou, Masanori
AU  - Satou M
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Funai, Kazuhito
AU  - Funai K
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Shiiya, Norihiko
AU  - Shiiya N
AD  - First Department of Surgery, Hamamatsu University School of Medicine.
FAU - Setou, Mitsutoshi
AU  - Setou M
AD  - Department of Cellular and Molecular Anatomy, Hamamatsu University School of 
      Medicine.
AD  - International Mass Imaging Center, Hamamatsu University School of Medicine.
AD  - Department of Systems Molecular Anatomy, Institute for Medical Photonics 
      Research, Hamamatsu University School of Medicine.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Cell Struct Funct
JT  - Cell structure and function
JID - 7608465
RN  - 0 (UBL3 protein, human)
RN  - 0 (Ubiquitin)
RN  - 0 (Ubiquitins)
SB  - IM
MH  - Animals
MH  - *Extracellular Vesicles/metabolism
MH  - Humans
MH  - Protein Processing, Post-Translational
MH  - Protein Transport
MH  - Ubiquitin/metabolism
MH  - Ubiquitins/genetics/*metabolism
PMC - PMC10511055
OTO - NOTNLM
OT  - UBL3
OT  - post-translational modification
OT  - protein sorting
OT  - small extracellular vesicles
OT  - ubiquitin-like protein
COIS- The authors declare that they have no conflicts of interest with the contents of 
      this article.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/26 06:00
PMCR- 2022/01/01
CRDT- 2022/02/24 05:39
PHST- 2022/02/24 05:39 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/csf/21078 [pii]
AID - 10.1247/csf.21078 [doi]
PST - ppublish
SO  - Cell Struct Funct. 2022;47(1):1-18. doi: 10.1247/csf.21078.