PMID- 35197569
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20221109
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 46
IP  - 6
DP  - 2022 Jun
TI  - Association of weight status and the risks of diabetes in adults: a systematic 
      review and meta-analysis of prospective cohort studies.
PG  - 1101-1113
LID - 10.1038/s41366-022-01096-1 [doi]
AB  - Obesity is a known risk factor for type 2 diabetes mellitus (T2DM); however, the 
      associations between underweight and T2DM and between weight status and 
      prediabetes have not been systematically reviewed. We aimed to estimate the 
      relative risks (RRs) of prediabetes/T2DM in underweight/overweight/obesity 
      relative to normal weight. PubMed, Embase, Web of Science, and Cochrane Library 
      were searched from inception to December 8, 2021. Prospective cohort studies with 
      a minimum 12-month follow-up period reporting the association between baseline 
      body mass index (BMI) categories and risk of prediabetes/T2DM in adults were 
      included. Study quality was assessed using the Newcastle-Ottawa Scale. The main 
      analyses of T2DM risk were performed using the ethnic-specific (Asian/non-Asian) 
      BMI classification and additional analyses of prediabetes/T2DM risk by including 
      all eligible studies. Random-effects models with inverse variance weighting were 
      used. Subgroup analyses and meta-regression were conducted to explore the 
      potential effects of pre-specified modifiers. The study protocol was registered 
      with PROSPERO (CRD42020215957). Eighty-four articles involving over 2.69 million 
      participants from 20 countries were included. The pooled RR of prediabetes risk 
      was 1.24 (95% CI: 1.19-1.28, I(2) = 9.7%, n = 5 studies) for overweight/obesity 
      vs. normal weight. The pooled RRs of T2DM based on the ethnic-specific BMI 
      categories were 0.93 (95% CI: 0.75-1.15, I(2) = 55.5%, n = 12) for underweight, 
      2.24 (95% CI: 1.95-2.56, I(2) = 92.0%, n = 47) for overweight, 4.56 (95% CI: 
      3.69-5.64, I(2) = 96%, n = 43) for obesity, and 22.97 (95% CI: 13.58-38.86, 
      I(2) = 92.1%, n = 6) for severe obesity vs. normal weight. Subgroup analyses 
      indicated that underweight is a protective factor against T2DM in non-Asians 
      (RR = 0.68, 95% CI: 0.40-0.99, I(2) = 56.1%, n = 6). The magnitude of the RR of 
      T2DM in overweight/obesity decreased with age and varied by region and the 
      assessment methods for weight and T2DM. Overweight/obesity was associated with an 
      increased prediabetes/T2DM risk. Further studies are required to confirm the 
      association between underweight and prediabetes/T2DM, particularly in Asian 
      populations.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Yu, Hong-Jie
AU  - Yu HJ
AD  - School of Nursing, the University of Hong Kong, Hong Kong, SAR, China.
FAU - Ho, Mandy
AU  - Ho M
AUID- ORCID: 0000-0002-4460-7969
AD  - School of Nursing, the University of Hong Kong, Hong Kong, SAR, China. 
      mandyho1@hku.hk.
FAU - Liu, Xiangxiang
AU  - Liu X
AD  - Shenzhen Second People's hospital, Shenzhen, China.
FAU - Yang, Jundi
AU  - Yang J
AD  - School of Nursing, the University of Hong Kong, Hong Kong, SAR, China.
FAU - Chau, Pui Hing
AU  - Chau PH
AD  - School of Nursing, the University of Hong Kong, Hong Kong, SAR, China.
FAU - Fong, Daniel Yee Tak
AU  - Fong DYT
AD  - School of Nursing, the University of Hong Kong, Hong Kong, SAR, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220223
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Humans
MH  - Obesity/complications/epidemiology
MH  - Overweight/complications/epidemiology
MH  - *Prediabetic State/complications/epidemiology
MH  - Prospective Studies
MH  - Thinness/complications/epidemiology
EDAT- 2022/02/25 06:00
MHDA- 2022/06/03 06:00
CRDT- 2022/02/24 05:40
PHST- 2021/10/11 00:00 [received]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/02/04 00:00 [revised]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2022/02/24 05:40 [entrez]
AID - 10.1038/s41366-022-01096-1 [pii]
AID - 10.1038/s41366-022-01096-1 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2022 Jun;46(6):1101-1113. doi: 10.1038/s41366-022-01096-1. 
      Epub 2022 Feb 23.