PMID- 35197747
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 29
IP  - 2
DP  - 2022 Feb
TI  - Contribution of genetic variant identified in HHEX gene in the overweight Saudi 
      patients confirmed with type 2 diabetes mellitus.
PG  - 804-808
LID - 10.1016/j.sjbs.2021.10.028 [doi]
AB  - BACKGROUND: The rs7932837 polymorphism in the Hematopoietically expressed 
      homeobox (HHEX) gene was discovered through genome-wide association studies and 
      is a promising candidate for type 2 diabetes mellitus (T2DM), which is one of the 
      risk factors for obesity and other complications. T2DM has been identified as a 
      heterogeneous and multifactorial disease characterized by insulin resistance and 
      secretion. AIM: The aim of this study was to investigate the rs7932837 
      polymorphism in the HHEX gene in overweight patients diagnosed with T2DM in the 
      Saudi Population. METHODS: In this case-control study, one hundred T2DM cases and 
      100 controls were selected based on inclusion and exclusion criteria. Genotyping 
      was performed with polymerase chair reaction-restriction fragment length 
      polymorphism analysis and statistical analysis was performed between T2DM cases 
      and controls for clinical characteristics, genotype and allele frequencies and 
      multiple logistic regression analysis. RESULTS: In this study, T2DM cases were 
      compared with healthy control subjects. Clinical characteristic analysis revealed 
      the statistical analysis between age, weight, BMI, FBG, HDL-c, TC, TG and family 
      history (p < 0.05). HWE analysis was in the accordance (p < 0.05). The rs7932837 
      polymorphism in the recessive model showed the positive association (AA + AG vs 
      AA: 2.22 [1.25-3.96] & p = 0.006) and none of the genotypes or alleles were in 
      the statistical association. Multiple logistic regression analysis revealed 
      positive association with age, BMI and FBG (p < 0.05). CONCLUSION: This study 
      concludes as rs7932837 polymorphism in the HHEX gene showed positive association 
      with recessive model and future studies recommend to carry out with large number 
      of sample size with additional polymorphisms in HHEX gene.
CI  - (c) 2021 The Author(s).
FAU - Alfaifi, Mohammed
AU  - Alfaifi M
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Khalid University, Abha, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20211022
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC8847961
OTO - NOTNLM
OT  - HHEX
OT  - Overweight and obesity
OT  - Rs7932837
OT  - T2DM
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/25 06:01
PMCR- 2021/10/22
CRDT- 2022/02/24 05:41
PHST- 2021/09/13 00:00 [received]
PHST- 2021/10/13 00:00 [revised]
PHST- 2021/10/13 00:00 [accepted]
PHST- 2022/02/24 05:41 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/25 06:01 [medline]
PHST- 2021/10/22 00:00 [pmc-release]
AID - S1319-562X(21)00906-2 [pii]
AID - 10.1016/j.sjbs.2021.10.028 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2022 Feb;29(2):804-808. doi: 10.1016/j.sjbs.2021.10.028. Epub 
      2021 Oct 22.