PMID- 35198005
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220225
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - Single Nucleotide Polymorphisms in the Human Leukocyte Antigen Region Are 
      Associated With Hemagglutination Inhibition Antibody Response to Influenza 
      Vaccine.
PG  - 790914
LID - 10.3389/fgene.2022.790914 [doi]
LID - 790914
AB  - Background: The annual death associated with seasonal influenza is 
      290,000-650,000 globally, which can be effectively reduced by influenza 
      vaccination. However, the protective hemagglutination inhibition (HAI) antibody 
      response to influenza vaccine is affected by many factors, among which single 
      nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA) region can 
      alter the antigen-presenting function of the HLA molecule, thus influencing the 
      process of antibody mounting against vaccine antigen. Methods: Healthy subjects 
      of the Han nationality were recruited and received seasonal trivalent influenza 
      vaccine. Paired serum samples collected on and approximately 28 days after 
      vaccination were tested in parallel by HAI assays. HLA alleles related to the 
      immune response to influenza vaccine reported in the previous literature were 
      summarized, and six corresponding tag SNPs were selected and genotyped using the 
      MassARRAY technology platform. Results: The effects of HLA SNPs on HAI antibody 
      response to influenza vaccine varied with different vaccine antigens. The AA 
      genotype of rs41547618 was correlated with low A/H1N1-specific antibody titer 
      compared with the GG + GA genotype (p = .007). The TT genotype of rs17885382 was 
      correlated with low A/H3N2-specific antibody titer compared with the CC + CT 
      genotype (p = .003). In addition, haplotype consisting of 
      rs41542812-rs17885382-rs2068205-rs41547618-rs6905837-rs9270299-CCTGCA was 
      correlated with non-responsiveness to influenza vaccine (OR = 2.39, 95% CI = 
      1.02-5.62). Conclusion: HLA SNPs were associated with HAI antibody response to 
      influenza vaccine, which can help in a better understanding of the varied 
      responsiveness to influenza vaccine in the population.
CI  - Copyright (c) 2022 Zhong, Wei, Li, Cheng, Wen, Wang and Shu.
FAU - Zhong, Shuyi
AU  - Zhong S
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Shenzhen, China.
FAU - Wei, Hejiang
AU  - Wei H
AD  - Institute for Viral Disease Control and Prevention, Chinese Center for Disease 
      Prevention and Control, Beijing, China.
FAU - Li, Mao
AU  - Li M
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Shenzhen, China.
FAU - Cheng, Yanhui
AU  - Cheng Y
AD  - Institute for Viral Disease Control and Prevention, Chinese Center for Disease 
      Prevention and Control, Beijing, China.
FAU - Wen, Simin
AU  - Wen S
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Shenzhen, China.
FAU - Wang, Dayan
AU  - Wang D
AD  - Institute for Viral Disease Control and Prevention, Chinese Center for Disease 
      Prevention and Control, Beijing, China.
FAU - Shu, Yuelong
AU  - Shu Y
AD  - School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, 
      Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20220207
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC8859407
OTO - NOTNLM
OT  - genetic epidemiology
OT  - hemagglutination inhibition antibody
OT  - human leukocyte antigen
OT  - influenza vaccine
OT  - single nucleotide polymorphisms
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/25 06:01
PMCR- 2022/02/07
CRDT- 2022/02/24 05:42
PHST- 2021/10/07 00:00 [received]
PHST- 2022/01/13 00:00 [accepted]
PHST- 2022/02/24 05:42 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/25 06:01 [medline]
PHST- 2022/02/07 00:00 [pmc-release]
AID - 790914 [pii]
AID - 10.3389/fgene.2022.790914 [doi]
PST - epublish
SO  - Front Genet. 2022 Feb 7;13:790914. doi: 10.3389/fgene.2022.790914. eCollection 
      2022.