PMID- 35198369 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220225 IS - 2213-0071 (Print) IS - 2213-0071 (Electronic) IS - 2213-0071 (Linking) VI - 36 DP - 2022 TI - Paradoxical worsening of nontuberculous mycobacterial disease after the discontinuation of antitumor necrosis factor therapy: A case report. PG - 101599 LID - 10.1016/j.rmcr.2022.101599 [doi] LID - 101599 AB - Antitumor necrosis factor-associated nontuberculous mycobacteria-immune reconstitution inflammatory syndrome (IRIS) has rarely been reported. An 84-year-old woman with a history of rheumatoid arthritis treated with etanercept was diagnosed with Mycobacterium avium complex (MAC) pulmonary disease six years before admission. Etanercept was discontinued two years ago because of MAC pulmonary disease progression and restarted nine months before admission because of worsening arthritis, again resulting in MAC pulmonary disease progression. Etanercept was discontinued again; however, the pulmonary disease progressed more rapidly. The condition was considered paradoxical worsening caused by IRIS due to etanercept discontinuation. The disease resolved quickly with chemotherapy for MAC. CI - (c) 2022 The Authors. Published by Elsevier Ltd. FAU - Nabeya, Daijiro AU - Nabeya D AD - Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. FAU - Kishaba, Tomoo AU - Kishaba T AD - Department of Respiratory Medicine, Okinawa Chubu Hospital, 281 Miyazato, Uruma, Okinawa, 904-2293, Japan. LA - eng PT - Case Reports DEP - 20220202 PL - England TA - Respir Med Case Rep JT - Respiratory medicine case reports JID - 101604463 PMC - PMC8844828 OTO - NOTNLM OT - Antitumor necrosis factor therapy OT - CT, computed tomography OT - HIV, human immunodeficiency virus OT - IRIS, immune reconstitution inflammatory syndrome OT - Immune reconstitution inflammatory syndrome OT - MAC, Mycobacterium avium complex OT - Mycobacterium avium complex OT - NTM, nontuberculous mycobacteria OT - Nontuberculous mycobacteria OT - Paradoxical response OT - TNF, tumor necrosis factor OT - Tumor necrosis factor-alpha COIS- None. EDAT- 2022/02/25 06:00 MHDA- 2022/02/25 06:01 PMCR- 2022/02/02 CRDT- 2022/02/24 05:43 PHST- 2021/08/24 00:00 [received] PHST- 2022/01/14 00:00 [revised] PHST- 2022/01/31 00:00 [accepted] PHST- 2022/02/24 05:43 [entrez] PHST- 2022/02/25 06:00 [pubmed] PHST- 2022/02/25 06:01 [medline] PHST- 2022/02/02 00:00 [pmc-release] AID - S2213-0071(22)00021-1 [pii] AID - 101599 [pii] AID - 10.1016/j.rmcr.2022.101599 [doi] PST - epublish SO - Respir Med Case Rep. 2022 Feb 2;36:101599. doi: 10.1016/j.rmcr.2022.101599. eCollection 2022.