PMID- 35198470
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220502
IS  - 2229-5178 (Print)
IS  - 2249-5673 (Electronic)
IS  - 2229-5178 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Jan-Feb
TI  - Proton Pump Inhibitor Induced Subacute Cutaneous Lupus Erythematosus: A Case 
      Series of 7 Patients and Brief Review of Literature.
PG  - 64-72
LID - 10.4103/idoj.idoj_237_21 [doi]
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) manifests with 
      erythematous, nonscarring, annular, or papulosquamous plaques. Proton pump 
      inhibitors (PPIs) are increasingly being incriminated in its causation, but 
      reports of similar nature from India are lacking. AIMS: To describe the 
      characteristics of seven patients with SCLE induced by PPIs and to review the 
      published cases in order to provide a better perspective of the association. 
      MATERIALS AND METHODS: We describe seven patients of PPI-induced SCLE, seen over 
      a period of 6 years. We also review the literature for additional data on 
      PPI-induced SCLE. The selected publications were reviewed, and relevant clinical 
      and laboratory data were extracted. RESULTS: Of the total seven cases, there were 
      four males and three females with a mean age of 60.2 +/- 5.5 years (range 53-70 
      years). Nine episodes of PPI-induced SCLE were recorded in the seven patients. Of 
      the initial episodes, esomeprazole was implicated in four, pantoprazole in two, 
      and rabeprazole in one patient. Latency period ranged from 2 weeks to 1 year 
      (mean 11.4 +/- 16.2 weeks). Morphology was described as annular scaly plaques in 
      six and papulosquamous in one. Antinuclear antibodies and anti-Ro antibodies were 
      positive in all patients. Naranjo probability scale was used in all patients; two 
      were categorized as definite and five as probable. Treatments included drug 
      withdrawal in six patients, topical steroids in one, systemic corticosteroids in 
      all seven, and hydroxychloroquine in one patient, used alone or in combinations. 
      Complete remission was achieved in six cases, while one had partial remission. 
      LIMITATION: Retrospective nature of this study and limited number of patients. 
      CONCLUSION: PPIs can trigger SCLE.
CI  - Copyright: (c) 2022 Indian Dermatology Online Journal.
FAU - Kaur, Sukhjot
AU  - Kaur S
AD  - Department of Dermatology, Venerology and Leprology, Dayanand Medical College and 
      Hospital, Ludhiana, Punjab, India.
FAU - Singla, Palvi
AU  - Singla P
AD  - Department of Dermatology, Venerology and Leprology, Dayanand Medical College and 
      Hospital, Ludhiana, Punjab, India.
FAU - Kaur, Sandeep
AU  - Kaur S
AD  - Department of Consultant Dermatologist, Dr. Jagroop Singh Hospital, Ludhiana, 
      Punjab, India.
FAU - Kansal, Amit
AU  - Kansal A
AD  - Kansal Arthritis and Rheumatology Clinic, Ludhiana, Punjab, India.
FAU - Bansal, Aditi
AU  - Bansal A
AD  - Department of Dermatology, Venerology and Leprology, Dayanand Medical College and 
      Hospital, Ludhiana, Punjab, India.
FAU - Singh, Aminder
AU  - Singh A
AD  - Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20220124
PL  - India
TA  - Indian Dermatol Online J
JT  - Indian dermatology online journal
JID - 101586880
PMC - PMC8809160
OTO - NOTNLM
OT  - Drug-Induced Subacute Cutaneous Lupus Erythematosus
OT  - SCLE
OT  - proton pump inhibitors
OT  - subacute cutaneous lupus erythematosus
COIS- There are no conflicts of interest.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/25 06:01
PMCR- 2022/01/24
CRDT- 2022/02/24 05:43
PHST- 2021/04/16 00:00 [received]
PHST- 2021/10/02 00:00 [accepted]
PHST- 2022/02/24 05:43 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/25 06:01 [medline]
PHST- 2022/01/24 00:00 [pmc-release]
AID - IDOJ-13-64 [pii]
AID - 10.4103/idoj.idoj_237_21 [doi]
PST - epublish
SO  - Indian Dermatol Online J. 2022 Jan 24;13(1):64-72. doi: 10.4103/idoj.idoj_237_21. 
      eCollection 2022 Jan-Feb.