PMID- 35198889
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220225
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 25
IP  - 2
DP  - 2022 Feb 18
TI  - A positive feed-forward loop between Fusobacterium nucleatum and ethanol 
      metabolism reprogramming drives laryngeal cancer progression and metastasis.
PG  - 103829
LID - 10.1016/j.isci.2022.103829 [doi]
LID - 103829
AB  - Alcohol consumption, which affects the structure and composition of the laryngeal 
      microbiota, is one of the most important risk factors for laryngeal squamous cell 
      cancer (LSCC). Our results demonstrated that high enrichment of Fusobacterium 
      nucleatum (F. nucleatum) in LSCC was associated with poor prognosis. F. nucleatum 
      increased miR-155-5p and miR-205-5p expression to suppress alcohol dehydrogenase 
      1B (ADH1B) and transforming growth factor beta receptor 2 (TGFBR2) expression by 
      activating innate immune signaling, resulting in ethanol metabolism reprogramming 
      to allow F. nucleatum accumulation and PI3K/AKT signaling pathway activation to 
      promote epithelial-mesenchymal transition, further exacerbating the uncontrolled 
      progression and metastasis of LSCC. Therefore, the positive feed-forward loop 
      between F. nucleatum and ethanol metabolism reprogramming promotes cell 
      proliferation, migration, and invasion to affect LSCC patient prognosis. The 
      amount of F. nucleatum is a potential prognostic biomarker, which yields valuable 
      insight into clinical management that may improve the oncologic outcome of 
      patients with LSCC.
CI  - (c) 2022 The Author(s).
FAU - Hsueh, Chi-Yao
AU  - Hsueh CY
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Huang, Qiang
AU  - Huang Q
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Shen, Yujie
AU  - Shen Y
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Sun, Ji
AU  - Sun J
AD  - Department of Pathology, Eye & ENT Hospital, Fudan University, 83 Fen Yang Road, 
      Shanghai 200031, China.
FAU - Lau, Hui-Ching
AU  - Lau HC
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Zhang, Duo
AU  - Zhang D
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Tang, Di
AU  - Tang D
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Wu, Chunping
AU  - Wu C
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Guo, Yang
AU  - Guo Y
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Huang, Huiying
AU  - Huang H
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Cao, Pengyu
AU  - Cao P
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, 83 Fen 
      Yang Road, Shanghai 200031, China.
LA  - eng
PT  - Journal Article
DEP - 20220130
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC8851092
OTO - NOTNLM
OT  - Cancer
OT  - Microbial metabolism
OT  - Mycology
COIS- None of the authors have any potential conflicts to disclose.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/25 06:01
PMCR- 2022/01/30
CRDT- 2022/02/24 05:45
PHST- 2021/09/08 00:00 [received]
PHST- 2021/12/10 00:00 [revised]
PHST- 2022/01/21 00:00 [accepted]
PHST- 2022/02/24 05:45 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/25 06:01 [medline]
PHST- 2022/01/30 00:00 [pmc-release]
AID - S2589-0042(22)00099-2 [pii]
AID - 103829 [pii]
AID - 10.1016/j.isci.2022.103829 [doi]
PST - epublish
SO  - iScience. 2022 Jan 30;25(2):103829. doi: 10.1016/j.isci.2022.103829. eCollection 
      2022 Feb 18.