PMID- 35199406
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20240214
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 24
IP  - 4
DP  - 2022 Apr
TI  - Cardiac energetics in patients with chronic heart failure and iron deficiency: an 
      in-vivo (31) P magnetic resonance spectroscopy study.
PG  - 716-723
LID - 10.1002/ejhf.2454 [doi]
AB  - AIMS: Iron deficiency (ID) is prevalent and adverse in chronic heart failure 
      (CHF) but few human studies have explored the myocardial mechanism(s) that 
      potentially underlie this adversity. Because mitochondrial oxidative 
      phosphorylation (OXPHOS) provides over 90% of the hearts adenosine triphosphate 
      (ATP), and iron is critical for OXPHOS, we hypothesized that patients with CHF 
      and ID would harbour greater cardiac energetic impairments than patients without 
      ID. METHODS AND RESULTS: Phosphorus magnetic resonance spectroscopy was used to 
      quantify the phosphocreatine (PCr) to ATP (PCr/ATP) ratio, an index of in-vivo 
      cardiac energetics, in CHF patients and healthy volunteers. Cardiac structure and 
      function was assessed from magnetic resonance short stack cines. Patients with 
      (n = 27) and without (n = 12) ID, and healthy volunteers (n = 11), were similar 
      with respect to age and gender. The PCr/ATP ratio was lower in patients with ID 
      (1.03 [0.83-1.38]) compared to those without ID (1.72 [1.51-2.26], p < 0.01) and 
      healthy volunteers (1.39 [1.10-3.68], p < 0.05). This was despite no difference 
      in cardiac structure and function between patients with and without ID, and 
      despite adjustment for the presence of anaemia, haemoglobin levels, cardiac 
      rhythm, or New York Heart Association (NYHA) class. In the total CHF cohort, the 
      PCr/ATP ratio correlated with ferritin levels (rho = 0.4, p < 0.01), and was 
      higher in NYHA class I than class II or III patients (p = 0.02). CONCLUSION: Iron 
      deficiency is associated with greater cardiac energetic impairment in patients 
      with CHF irrespective of anaemia and cardiac structure and function. Suppression 
      of cardiac mitochondrial function might therefore be a mechanism via which ID 
      worsens human CHF.
CI  - (c) 2022 The Authors. European Journal of Heart Failure published by John Wiley & 
      Sons Ltd on behalf of European Society of Cardiology.
FAU - Papalia, Francesco
AU  - Papalia F
AD  - King's College London British Heart Foundation Centre of Excellence, School of 
      Cardiovascular Medicine and Sciences, James Black Centre, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
FAU - Jouhra, Fadi
AU  - Jouhra F
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
AD  - Lewisham & Greenwich NHS Foundation Trust, London, UK.
AD  - St George's University Hospitals NHS Foundation Trust, London, UK.
FAU - Amin-Youssef, George
AU  - Amin-Youssef G
AD  - King's College Hospital NHS Foundation Trust, London, UK.
FAU - Shah, Ajay M
AU  - Shah AM
AD  - King's College London British Heart Foundation Centre of Excellence, School of 
      Cardiovascular Medicine and Sciences, James Black Centre, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
AD  - King's College Hospital NHS Foundation Trust, London, UK.
FAU - Charles-Edwards, Geoffrey
AU  - Charles-Edwards G
AD  - School of Imaging Sciences and Biomedical Engineering, King's College, London, 
      UK.
FAU - Okonko, Darlington O
AU  - Okonko DO
AD  - King's College London British Heart Foundation Centre of Excellence, School of 
      Cardiovascular Medicine and Sciences, James Black Centre, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
AD  - King's College Hospital NHS Foundation Trust, London, UK.
LA  - eng
GR  - CH/1999001/11735/BHF_/British Heart Foundation/United Kingdom
GR  - FS/14/77/30913/BHF_/British Heart Foundation/United Kingdom
GR  - FS/17/77/33128/BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220308
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
CIN - Eur J Heart Fail. 2022 Apr;24(4):724-726. PMID: 35262258
CIN - Eur J Heart Fail. 2022 Oct;24(10):1992. PMID: 35703335
CIN - Eur J Heart Fail. 2022 Oct;24(10):1992-1993. PMID: 35853839
MH  - Adenosine Triphosphate
MH  - *Anemia/complications
MH  - *Anemia, Iron-Deficiency/complications
MH  - Chronic Disease
MH  - *Heart Failure
MH  - Humans
MH  - *Iron Deficiencies
MH  - Magnetic Resonance Spectroscopy
PMC - PMC9310591
OTO - NOTNLM
OT  - Cardiac energetics
OT  - Heart failure
OT  - Iron
OT  - Spectroscopy
EDAT- 2022/02/25 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/07/25
CRDT- 2022/02/24 05:48
PHST- 2022/01/25 00:00 [revised]
PHST- 2021/10/21 00:00 [received]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/02/24 05:48 [entrez]
PHST- 2022/07/25 00:00 [pmc-release]
AID - EJHF2454 [pii]
AID - 10.1002/ejhf.2454 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2022 Apr;24(4):716-723. doi: 10.1002/ejhf.2454. Epub 2022 Mar 
      8.