PMID- 35199863
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220531
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 45
IP  - 4
DP  - 2022 Apr
TI  - Surgical left atrial appendage occlusion in patients with left ventricular assist 
      device.
PG  - 567-570
LID - 10.1111/pace.14471 [doi]
AB  - BACKGROUND: Thromboembolic (TE) events are among the most common and devastating 
      adverse events in patients with continuous-flow left ventricular assist device 
      (cf-LVAD). Given the high burden of AF among cf-LVAD patients, we sought to 
      evaluate the effect of concomitant surgical LAAO in patients receiving cf-LVAD. 
      METHODS: A systematic search using electronic databases was performed using the 
      keywords: "left atrial appendage occlusion" and "left ventricular assist device." 
      Statistical analysis was performed using metapackage for R version 4.0 and 
      Rstudio version 1.2. Mantel-Haenszel risk ratio (RR) random-effects model was 
      used to summarize data between two groups. The primary outcomes included: (a) 
      stroke; (b) LVAD pump thrombosis; (c) all-cause mortality RESULTS: Three studies 
      with a total of 305 patients (LAAO = 68 and No-LAAO = 237) were included in the 
      analysis. HeartMate II (39%) and Heartware (27.5%) were the two most common 
      cf-LVADs utilized, while only 5% received HeartMate III. At a mean follow up of 
      1.47 years, LAAO group had a lower risk of stroke (8.8% vs. 15.2%, RR 0.64; 95% 
      CI 0.28-1.49), LVAD pump thrombosis (1.5% vs. 3.8%, RR 0.28; 95% CI 0.05-1.55) 
      and all-cause mortality (5.9% vs. 20.2%, RR 0.69; 95% CI 0.19-2.52) when compared 
      with no-LAAO group, but the difference did not reach statistical significance. 
      CONCLUSION: Concomitant surgical LAAO at the time of cf-LVAD implantation 
      demonstrated a trend toward positive outcomes and was not associated with adverse 
      outcomes during the follow-up period, though the results were not statistically 
      significant.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Kewcharoen, Jakrin
AU  - Kewcharoen J
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, California, USA.
FAU - Shah, Kuldeep
AU  - Shah K
AD  - Department of Cardiovascular Medicine, Beaumont Hospital, Oakland University 
      William Beaumont School of Medicine, Royal Oak, Michigan, USA.
FAU - Bhardwaj, Rahul
AU  - Bhardwaj R
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, California, USA.
FAU - Contractor, Tahmeed
AU  - Contractor T
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, California, USA.
FAU - Turagam, Mohit K
AU  - Turagam MK
AD  - Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New 
      York, New York, USA.
FAU - Mandapati, Ravi
AU  - Mandapati R
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, California, USA.
FAU - Lakkireddy, Dhanunjaya
AU  - Lakkireddy D
AUID- ORCID: 0000-0002-1492-2693
AD  - Kansas City Heart Rhythm Institute and Research Foundation, Kansas City, Kansas, 
      USA.
FAU - Garg, Jalaj
AU  - Garg J
AUID- ORCID: 0000-0002-6857-7418
AD  - Division of Cardiology, Cardiac Arrhythmia Service, Loma Linda University Health, 
      Loma Linda, California, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220302
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - *Atrial Appendage/surgery
MH  - *Heart Failure/complications
MH  - *Heart-Assist Devices/adverse effects
MH  - Humans
MH  - Retrospective Studies
MH  - *Stroke/complications
MH  - *Thromboembolism/etiology
MH  - *Thrombosis/etiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - LVAD
OT  - heartmate
OT  - left atrial appendage occlusion
OT  - pump thrombosis
OT  - stroke
EDAT- 2022/02/25 06:00
MHDA- 2022/04/08 06:00
CRDT- 2022/02/24 08:43
PHST- 2022/01/16 00:00 [revised]
PHST- 2021/10/19 00:00 [received]
PHST- 2022/02/13 00:00 [accepted]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2022/02/24 08:43 [entrez]
AID - 10.1111/pace.14471 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2022 Apr;45(4):567-570. doi: 10.1111/pace.14471. Epub 
      2022 Mar 2.