PMID- 35200591 OWN - NLM STAT- MEDLINE DCOM- 20220301 LR - 20220301 IS - 1718-7729 (Electronic) IS - 1198-0052 (Print) IS - 1198-0052 (Linking) VI - 29 IP - 2 DP - 2022 Feb 13 TI - Patterns of Pretreatment Diagnostic Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Non-Small Cell Lung Cancer (NSCLC): Special Characteristics in the COVID Pandemic and Influence on Outcomes. PG - 1080-1092 LID - 10.3390/curroncol29020092 [doi] AB - The pandemic raised a discussion about the postponement of medical interventions for non-small cell lung cancer (NSCLC). We analyzed the characteristics of pretreatment diagnostic assessment in the pandemic and the influence of diagnostic assessment on outcomes. A total of 96 patients with stereotactic body radiation therapy (SBRT) for NSCLC were included. The number of patients increased from mean 0.9 (2012-2019) to 1.45 per month in the COVID era (p < 0.05). Pandemic-related factors (contact reduction, limited intensive care unit resources) might have influenced clinical decision making towards SBRT. The time from pretreatment assessment (multidisciplinary tumor board decision, bronchoscopy, planning CT) to SBRT was longer during the COVID period (p < 0.05). Reduced services, staff shortage, or appointment management to mitigate infection risks might explain this finding. Overall survival, progression-free survival, locoregional progression-free survival, and distant progression-free survival were superior in patients who received a PET/CT scan prior to SBRT (p < 0.05). This supports that SBRT guidelines advocate the acquisition of a PET/CT scan. A longer time from PET/CT scan/conventional staging to SBRT (<10 vs. >/=10 weeks) was associated with worse locoregional control (p < 0.05). The postponement of diagnostic or therapeutic measures in the pandemic should be discussed cautiously. Patient- and tumor-related features should be evaluated in detail. FAU - Habermann, Felix-Nikolai Oschinka Jegor AU - Habermann FOJ AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Schmitt, Daniela AU - Schmitt D AUID- ORCID: 0000-0002-9657-0715 AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Failing, Thomas AU - Failing T AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Fischer, Jann AU - Fischer J AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Ziegler, David Alexander AU - Ziegler DA AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Fischer, Laura Anna AU - Fischer LA AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Alt, Niklas Josua AU - Alt NJ AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Muster, Julian AU - Muster J AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Donath, Sandra AU - Donath S AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Hille, Andrea AU - Hille A AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Schirmer, Markus Anton AU - Schirmer MA AUID- ORCID: 0000-0003-1375-4496 AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Guhlich, Manuel AU - Guhlich M AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - El Shafie, Rami A AU - El Shafie RA AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Rieken, Stefan AU - Rieken S AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Leu, Martin AU - Leu M AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. FAU - Droge, Leif Hendrik AU - Droge LH AD - Department of Radiotherapy and Radiation Oncology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. AD - Comprehensive Cancer Center Niedersachsen (CCC-N), University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany. LA - eng PT - Journal Article DEP - 20220213 PL - Switzerland TA - Curr Oncol JT - Current oncology (Toronto, Ont.) JID - 9502503 SB - IM MH - *COVID-19 MH - *Carcinoma, Non-Small-Cell Lung/pathology MH - Follow-Up Studies MH - Humans MH - *Lung Neoplasms/pathology MH - Neoplasm Staging MH - Pandemics MH - Positron Emission Tomography Computed Tomography MH - Positron-Emission Tomography MH - *Radiosurgery/adverse effects MH - SARS-CoV-2 PMC - PMC8871078 OTO - NOTNLM OT - coronavirus disease 2019 OT - diagnostic assessment OT - non-small cell lung cancer OT - outcomes OT - pandemic OT - positron emission tomography/computed tomography scan OT - staging examinations OT - stereotactic body radiation therapy COIS- The authors declare no conflict of interest. EDAT- 2022/02/25 06:00 MHDA- 2022/03/03 06:00 PMCR- 2022/02/13 CRDT- 2022/02/24 12:20 PHST- 2022/01/03 00:00 [received] PHST- 2022/01/29 00:00 [revised] PHST- 2022/02/11 00:00 [accepted] PHST- 2022/02/24 12:20 [entrez] PHST- 2022/02/25 06:00 [pubmed] PHST- 2022/03/03 06:00 [medline] PHST- 2022/02/13 00:00 [pmc-release] AID - curroncol29020092 [pii] AID - curroncol-29-00092 [pii] AID - 10.3390/curroncol29020092 [doi] PST - epublish SO - Curr Oncol. 2022 Feb 13;29(2):1080-1092. doi: 10.3390/curroncol29020092.