PMID- 35200662
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 20
IP  - 2
DP  - 2022 Feb 10
TI  - Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia 
      morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis 
      Mouse Model.
LID - 10.3390/md20020133 [doi]
LID - 133
AB  - In this study, we investigated the anti-allergic effects of 
      3,4-dihydroxybenzaldehyde (DHB) isolated from the marine red alga, Polysiphonia 
      morrowii, in mouse bone-marrow-derived cultured mast cells (BMCMCs) and passive 
      cutaneous anaphylaxis (PCA) in anti-dinitrophenyl (DNP) immunoglobulin E 
      (IgE)-sensitized mice. DHB inhibited IgE/bovine serum albumin (BSA)-induced 
      BMCMCs degranulation by reducing the release of beta-hexosaminidase without inducing 
      cytotoxicity. Further, DHB dose-dependently decreased the IgE binding and 
      high-affinity IgE receptor (FcepsilonRI) expression and FcepsilonRI-IgE binding on the 
      surface of BMCMCs. Moreover, DHB suppressed the secretion and/or the expression 
      of the allergic cytokines, interleukin (IL)-4, IL-5, IL-6, IL-13, and tumor 
      necrosis factor (TNF)-alpha, and the chemokine, thymus activation-regulated chemokine 
      (TARC), by regulating the phosphorylation of IkappaBalpha and the translocation of 
      cytoplasmic NF-kappaB into the nucleus. Furthermore, DHB attenuated the passive 
      cutaneous anaphylactic (PCA) reaction reducing the exuded Evans blue amount in 
      the mouse ear stimulated by IgE/BSA. These results suggest that DHB is a 
      potential therapeutic candidate for the prevention and treatment of type I 
      allergic disorders.
FAU - Kim, Eun-A
AU  - Kim EA
AD  - Jeju Marine Research Center, Korea Institute of Ocean Science & Technology 
      (KIOST), Jeju 63349, Korea.
FAU - Han, Eui-Jeong
AU  - Han EJ
AD  - Research Center for Healthcare and Biomedical Engineering, Chonnam National 
      University, Yeosu 59626, Korea.
AD  - Department of Food Technology and Nutrition, Chonnam National University, Yeosu 
      59626, Korea.
FAU - Kim, Junseong
AU  - Kim J
AD  - Jeju Marine Research Center, Korea Institute of Ocean Science & Technology 
      (KIOST), Jeju 63349, Korea.
FAU - Fernando, Ilekuttige Priyan Shanura
AU  - Fernando IPS
AD  - Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, 
      Korea.
FAU - Oh, Jae-Young
AU  - Oh JY
AD  - Food Safety and Processing Research Division, National Institute of Fisheries 
      Science, Busan 46083, Korea.
FAU - Kim, Kil-Nam
AU  - Kim KN
AUID- ORCID: 0000-0002-7712-7697
AD  - Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
FAU - Ahn, Ginnae
AU  - Ahn G
AD  - Department of Food Technology and Nutrition, Chonnam National University, Yeosu 
      59626, Korea.
AD  - Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, 
      Korea.
FAU - Heo, Soo-Jin
AU  - Heo SJ
AD  - Jeju Marine Research Center, Korea Institute of Ocean Science & Technology 
      (KIOST), Jeju 63349, Korea.
AD  - Department of Marine Biology, University of Science and Technology, Daejeon 
      34113, Korea.
LA  - eng
GR  - PE99922/National Research Foundation of Korea/
GR  - PE99922/Korea Institute of Ocean Science and Technology/
PT  - Journal Article
DEP - 20220210
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Benzaldehydes)
RN  - 0 (Catechols)
RN  - 0 (Cytokines)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4PVP2HCH4T (protocatechualdehyde)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/administration & dosage/isolation & 
      purification/*pharmacology
MH  - Benzaldehydes/administration & dosage/isolation & purification/*pharmacology
MH  - Catechols/administration & dosage/isolation & purification/*pharmacology
MH  - Cells, Cultured
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Passive Cutaneous Anaphylaxis/drug effects/immunology
MH  - Rhodophyta/*metabolism
MH  - Serum Albumin, Bovine/immunology
PMC - PMC8875385
OTO - NOTNLM
OT  - 3,4-dihydroxybenzaldehyde
OT  - Polysiphonia morrowii
OT  - bone marrow-derived cultured mast cells
OT  - immunoglobulin E
OT  - passive cutaneous anaphylaxis
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/25 06:00
MHDA- 2022/03/17 06:00
PMCR- 2022/02/10
CRDT- 2022/02/24 12:20
PHST- 2021/12/28 00:00 [received]
PHST- 2022/02/07 00:00 [revised]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/02/24 12:20 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2022/02/10 00:00 [pmc-release]
AID - md20020133 [pii]
AID - marinedrugs-20-00133 [pii]
AID - 10.3390/md20020133 [doi]
PST - epublish
SO  - Mar Drugs. 2022 Feb 10;20(2):133. doi: 10.3390/md20020133.