PMID- 35202220
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220228
IS  - 2414-6366 (Electronic)
IS  - 2414-6366 (Linking)
VI  - 7
IP  - 2
DP  - 2022 Feb 11
TI  - Francisella sp., a Close Relative of Francisella orientalis, Causing Septicemia 
      with Cholestatic Hepatitis in a Patient with Anti-Interferon-gamma (IFN-gamma) 
      Autoantibodies.
LID - 10.3390/tropicalmed7020025 [doi]
LID - 25
AB  - Francisella is an intracellular, fastidious, Gram-negative bacterium that is 
      difficult to identify using routine microbiological methods in the laboratory. We 
      studied the isolation of Francisella sp. (strain IDAMR664) from the blood of a 
      patient with anti-interferon-gamma (IFN-gamma) autoantibodies who presented with 
      septicemia and cholestatic hepatitis. Analysis of the strain IDAMR664 genome 
      sequence revealed the isolate was closely related to the strain GA01-2794 that 
      had been isolated from a human in the USA. In addition, it was clustered with F. 
      orientalis, a fish pathogen. The isolate contained several virulence factors and 
      had Francisella pathogenicity island pattern no. 3.
FAU - Kajeekul, Rattagan
AU  - Kajeekul R
AUID- ORCID: 0000-0001-5067-5389
AD  - Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 
      30000, Thailand.
FAU - Insiripong, Somchai
AU  - Insiripong S
AD  - Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 
      30000, Thailand.
FAU - Riwlord, Athita
AU  - Riwlord A
AD  - Clinical Microbiology Laboratory, Department of Medical Technology, Maharat 
      Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, Thailand.
FAU - Poomchuchit, Suleeporn
AU  - Poomchuchit S
AD  - Department of Community Health, Faculty of Public Health, Chalermphrakiat Sakon 
      Nakhon Province Campus, Kasetsart University, Sakon Nakhon 47000, Thailand.
FAU - Kerdsin, Anusak
AU  - Kerdsin A
AUID- ORCID: 0000-0003-1055-3656
AD  - Department of Community Health, Faculty of Public Health, Chalermphrakiat Sakon 
      Nakhon Province Campus, Kasetsart University, Sakon Nakhon 47000, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20220211
PL  - Switzerland
TA  - Trop Med Infect Dis
JT  - Tropical medicine and infectious disease
JID - 101709042
PMC - PMC8874608
OTO - NOTNLM
OT  - Francisella philomiragia
OT  - anti-interferon-gamma autoantibodies
OT  - genome
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/25 06:00
MHDA- 2022/02/25 06:01
PMCR- 2022/02/11
CRDT- 2022/02/24 17:21
PHST- 2021/12/29 00:00 [received]
PHST- 2022/02/01 00:00 [revised]
PHST- 2022/02/08 00:00 [accepted]
PHST- 2022/02/24 17:21 [entrez]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/02/25 06:01 [medline]
PHST- 2022/02/11 00:00 [pmc-release]
AID - tropicalmed7020025 [pii]
AID - tropicalmed-07-00025 [pii]
AID - 10.3390/tropicalmed7020025 [doi]
PST - epublish
SO  - Trop Med Infect Dis. 2022 Feb 11;7(2):25. doi: 10.3390/tropicalmed7020025.