PMID- 35202547
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221107
IS  - 0891-9887 (Print)
IS  - 0891-9887 (Linking)
VI  - 35
IP  - 6
DP  - 2022 Nov
TI  - Structural Basal Ganglia Correlates of Subjective Fatigue in Middle-Aged and 
      Older Adults.
PG  - 800-809
LID - 10.1177/08919887211070264 [doi]
AB  - OBJECTIVE: Fatigue is among the most common complaints in community-dwelling 
      older adults, yet its etiology is poorly understood. Based on models implicating 
      frontostriatal pathways in fatigue pathogenesis, we hypothesized that smaller 
      basal ganglia volume would be associated with higher levels of subjective fatigue 
      and reduced set-shifting in middle-aged and older adults without dementia or 
      other neurologic conditions. METHODS: Forty-eight non-demented middle-aged and 
      older adults (M(age) = 68.1, SD = 9.4; M(MMSE) = 27.3, SD = 1.9) completed the 
      Fatigue Symptom Inventory, set-shifting measures, and structural MRI as part of a 
      clinical evaluation for subjective cognitive complaints. Associations were 
      examined cross-sectionally. RESULTS: Linear regression analyses showed that 
      smaller normalized basal ganglia volumes were associated with more severe fatigue 
      (beta = -.29, P = .041) and poorer Trail Making Test B-A (TMT B-A) performance (beta = 
      .30, P = .033) controlling for depression, sleep quality, vascular risk factors, 
      and global cognitive status. Putamen emerged as a key structure linked with both 
      fatigue (r = -.43, P = .003) and TMT B-A (beta = .35, P = .021). The link between 
      total basal ganglia volume and reduced TMT B-A was particularly strong in 
      clinically fatigued patients. CONCLUSION: This study is among the first to show 
      that reduced basal ganglia volume is an important neurostructural correlate of 
      subjective fatigue in physically able middle-aged and older adults without 
      neurological conditions. Findings suggest that fatigue and rapid set-shifting 
      deficits may share common neural underpinnings involving the basal ganglia, and 
      provide a framework for studying the neuropathogenesis and treatment of 
      subjective fatigue.
FAU - Banerjee, Nikhil
AU  - Banerjee N
AUID- ORCID: 0000-0001-7314-7490
AD  - Department of Neurology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Kaur, Sonya
AU  - Kaur S
AD  - Department of Neurology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Saporta, Anita
AU  - Saporta A
AUID- ORCID: 0000-0002-5155-1051
AD  - Department of Neurology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Lee, Sang H
AU  - Lee SH
AD  - Department of Radiology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Alperin, Noam
AU  - Alperin N
AD  - Department of Radiology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
FAU - Levin, Bonnie E
AU  - Levin BE
AD  - Department of Neurology, 12235University of Miami Miller School of Medicine, 
      Miami, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220224
PL  - United States
TA  - J Geriatr Psychiatry Neurol
JT  - Journal of geriatric psychiatry and neurology
JID - 8805645
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Basal Ganglia/diagnostic imaging/pathology
MH  - Trail Making Test
MH  - *Fatigue/diagnostic imaging/pathology
MH  - Independent Living
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - basal ganglia
OT  - fatigue
OT  - older adults
OT  - putamen
OT  - set-shifting
EDAT- 2022/02/25 06:00
MHDA- 2022/11/02 06:00
CRDT- 2022/02/24 20:10
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/02/24 20:10 [entrez]
AID - 10.1177/08919887211070264 [doi]
PST - ppublish
SO  - J Geriatr Psychiatry Neurol. 2022 Nov;35(6):800-809. doi: 
      10.1177/08919887211070264. Epub 2022 Feb 24.