PMID- 35202930
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220413
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 282
DP  - 2022 Mar
TI  - Exploiting autophagy-regulative nanomaterials for activation of dendritic cells 
      enables reinforced cancer immunotherapy.
PG  - 121434
LID - S0142-9612(22)00073-4 [pii]
LID - 10.1016/j.biomaterials.2022.121434 [doi]
AB  - Dendritic cells (DCs), as the most powerful antigen presenting cells, play a 
      critical role in regulating immune response and anti-tumor process. However, the 
      immunosuppressive cells and factors resided in the tumor microenvironment (TME) 
      pose various challenges that can subvert competent DC function comprising antigen 
      presentation and immune initiation. In this setting, developing potent strategies 
      to improve the function of DCs is critically required for improving the efficacy 
      of tumor immunotherapy. Autophagy is found to be closely associated to the 
      various functions of DCs under physiological and pathological conditions. 
      Especially, nanomaterials (NMs) can engage in the disorder and regularity of 
      autophagy to modulate their metabolism and function of DCs. Reasonable design of 
      nanomaterials with autophagy regulation is of great significance to activate DCs 
      and enhance its immunological functions, provoking robust and durable antitumor 
      immunity. In this review, we study the design and optimization of nanomaterials 
      with the function of regulating DCs autophagy, discuss the main mechanism of DCs 
      autophagy induced by nanomaterials and its application in tumor immunotherapy, 
      promoting the progress and development of cancer immunotherapy strategies in the 
      future.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Guan, Ying-Hua
AU  - Guan YH
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR 
      China.
FAU - Wang, Na
AU  - Wang N
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR 
      China.
FAU - Deng, Zhen-Wei
AU  - Deng ZW
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR 
      China.
FAU - Chen, Xi-Guang
AU  - Chen XG
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR 
      China; Qingdao National Laboratory for Marine Science and Technology, Qingdao, 
      266000, PR China.
FAU - Liu, Ya
AU  - Liu Y
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, PR 
      China. Electronic address: yaliu@ouc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220218
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
SB  - IM
MH  - Autophagy
MH  - Dendritic Cells
MH  - Humans
MH  - Immunotherapy
MH  - *Nanostructures
MH  - *Neoplasms/metabolism
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Activation
OT  - Autophagy
OT  - Cancer immunotherapy
OT  - Dendritic cells
OT  - Nanomaterials
EDAT- 2022/02/25 06:00
MHDA- 2022/04/14 06:00
CRDT- 2022/02/24 20:13
PHST- 2021/10/11 00:00 [received]
PHST- 2022/01/15 00:00 [revised]
PHST- 2022/02/17 00:00 [accepted]
PHST- 2022/02/25 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/02/24 20:13 [entrez]
AID - S0142-9612(22)00073-4 [pii]
AID - 10.1016/j.biomaterials.2022.121434 [doi]
PST - ppublish
SO  - Biomaterials. 2022 Mar;282:121434. doi: 10.1016/j.biomaterials.2022.121434. Epub 
      2022 Feb 18.