PMID- 35203391
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220531
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 4
DP  - 2022 Feb 21
TI  - Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in 
      Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac 
      Dysfunction.
LID - 10.3390/cells11040742 [doi]
LID - 742
AB  - Mediators of cardiac injury in preeclampsia are not well understood. Preeclamptic 
      women have decreased cardiac global longitudinal strain (GLS), a sensitive 
      measure of systolic function that indicates fibrosis and tissue injury. GLS is 
      worse in preeclampsia compared to gestational hypertension, despite comparable 
      blood pressure, suggesting that placental factors may be involved. We previously 
      showed that Activin A, a pro-fibrotic factor produced in excess by the placenta 
      in preeclampsia, predicts impaired GLS postpartum. Here, we hypothesized that 
      chronic excess levels of Activin A during pregnancy induces cardiac dysfunction. 
      Rats were assigned to sham or activin A infusion (1.25-6 microg/day) on a gestational 
      day (GD) 14 (n = 6-10/group). All animals underwent blood pressure measurement 
      and comprehensive echocardiography followed by euthanasia and the collection of 
      tissue samples on GD 19. Increased circulating activin A (sham: 0.59 +/- 0.05 
      ng/mL, 6 microg/day: 2.8 +/- 0.41 ng/mL, p < 0.01) was associated with impaired GLS 
      (Sham: -22.1 +/- 0.8%, 6 microg/day: -14.7 +/- 1.14%, p < 0.01). Activin A infusion (6 
      microg/day) increased beta-myosin heavy chain expression in heart tissue, indicating 
      cardiac injury. In summary, our findings indicate that increasing levels of 
      activin A during pregnancy induces cardiac dysfunction and supports the concept 
      that activin A may serve as a possible mediator of PE-induced cardiac 
      dysfunction.
FAU - Bakrania, Bhavisha A
AU  - Bakrania BA
AUID- ORCID: 0000-0002-2534-004X
AD  - UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, 
      Brisbane 4029, Australia.
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39216, USA.
FAU - Palei, Ana C
AU  - Palei AC
AUID- ORCID: 0000-0002-2669-5301
AD  - Department of Surgery, University of Mississippi Medical Center, Jackson, MS 
      39216, USA.
FAU - Bhattarai, Umesh
AU  - Bhattarai U
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39216, USA.
FAU - Chen, Yingjie
AU  - Chen Y
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39216, USA.
FAU - Granger, Joey P
AU  - Granger JP
AD  - Department of Physiology and Biophysics, University of Mississippi Medical 
      Center, Jackson, MS 39216, USA.
FAU - Shahul, Sajid
AU  - Shahul S
AD  - Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 
      60637, USA.
LA  - eng
GR  - R01 HL139797/HL/NHLBI NIH HHS/United States
GR  - 18POST33990293/American Heart Association/
GR  - U54 GM115428/GM/NIGMS NIH HHS/United States
GR  - P01 HL051971/HL/NHLBI NIH HHS/United States
GR  - P20 GM104357/GM/NIGMS NIH HHS/United States
GR  - R01 HL148191/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220221
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (activin A)
RN  - 104625-48-1 (Activins)
SB  - IM
MH  - *Activins/blood
MH  - Animals
MH  - Female
MH  - *Heart Diseases/etiology
MH  - Humans
MH  - Placenta
MH  - *Pre-Eclampsia/pathology
MH  - Pregnancy
MH  - Rats
PMC - PMC8870359
OTO - NOTNLM
OT  - activin A
OT  - cardiac dysfunction
OT  - placental factors
OT  - preeclampsia
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/02/21
CRDT- 2022/02/25 01:01
PHST- 2022/01/21 00:00 [received]
PHST- 2022/02/16 00:00 [revised]
PHST- 2022/02/17 00:00 [accepted]
PHST- 2022/02/25 01:01 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/02/21 00:00 [pmc-release]
AID - cells11040742 [pii]
AID - cells-11-00742 [pii]
AID - 10.3390/cells11040742 [doi]
PST - epublish
SO  - Cells. 2022 Feb 21;11(4):742. doi: 10.3390/cells11040742.