PMID- 35203597
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220401
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 2
DP  - 2022 Feb 6
TI  - Inflammation Status and Body Composition Predict Two-Year Mortality of Patients 
      with Locally Advanced Head and Neck Squamous Cell Carcinoma under Provision of 
      Recommended Energy Intake during Concurrent Chemoradiotherapy.
LID - 10.3390/biomedicines10020388 [doi]
LID - 388
AB  - Only few prospective cohort trials have evaluated the risk factors for the 2-year 
      mortality rate between two patient subgroups with locally advanced head and neck 
      squamous cell carcinoma (LAHNSCC): oral cavity cancer with adjuvant concurrent 
      chemoradiotherapy (CCRT) (OCC) and non-oral cavity cancer with primary CCRT 
      (NOCC), under the recommended calorie intake and investigated the interplay among 
      calorie supply, nutrition-inflammation biomarkers (NIBs), and total body 
      composition change (TBC), as assessed using dual-energy X-ray absorptiometry 
      (DXA). Patients with LAHNSCC who consumed at least 25 kcal/kg/day during CCRT 
      were prospectively recruited. Clinicopathological variables, blood NIBs, 
      CCRT-related factors, and TBC data before and after treatment were collected. 
      Factor analysis was performed to reduce the number of anthropometric and 
      DXA-derived measurements. Cox proportional hazards models were used for analysis. 
      We enrolled 123 patients with LAHNSCC (69 with OCC and 54 with NOCC). The mean 
      daily calorie intake correlated with the treatment interval changes in total body 
      muscle and fat. Patients consuming >/=30 kcal/kg/day had lower pretreatment levels 
      but exhibited fewer treatment interval changes in anthropometric and DXA 
      measurements than patients consuming <30 kcal/kg/day. In the multivariate 
      analysis of the 2-year mortality rate, the prognostic influence of the 
      recommended calorie intake could not be confirmed, but different risk factors 
      (performance status, pretreatment platelet-to-lymphocyte ratio, and treatment 
      interval body muscle changes in patients with OCC; age, pretreatment 
      neutrophil-to-lymphocyte ratio, and body fat storage in patients with NOCC) 
      showed independent effects. Therefore, the inflammation status and body 
      composition, but not the recommended calorie supply, contribute to the 2-year 
      mortality rate for patients with LAHNSCC receiving CCRT.
FAU - Lin, Yu-Ching
AU  - Lin YC
AD  - Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, 
      College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.
AD  - Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, 
      Keelung 20401, Taiwan.
FAU - Wang, Cheng-Hsu
AU  - Wang CH
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Ling, Hang Huong
AU  - Ling HH
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Pan, Yi-Ping
AU  - Pan YP
AD  - Department of Nutrition, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
FAU - Chang, Pei-Hung
AU  - Chang PH
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Chou, Wen-Chi
AU  - Chou WC
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Linkou & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Chen, Fang-Ping
AU  - Chen FP
AUID- ORCID: 0000-0001-5228-5755
AD  - Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, 
      Keelung 20401, Taiwan.
AD  - Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung 
      20401, Taiwan.
AD  - Healthy Aging Research Center, College of Medicine, Chang Gung University, 
      Taoyuan 333007, Taiwan.
FAU - Yeh, Kun-Yun
AU  - Yeh KY
AUID- ORCID: 0000-0001-5572-7897
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
LA  - eng
GR  - CMRPG2E0101-CMRPG2E0103, CMRPG2J0171, CMRPG2G0611, and CORPG2F0011-13/Chang Gang 
      Memorial Hospital, Keelung, Taiwan/
GR  - the Ministry of Science and Technology, Taiwan/MOST 108-2314-B-182A-018-MY3/
PT  - Journal Article
DEP - 20220206
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC8962429
OTO - NOTNLM
OT  - body composition
OT  - calorie supply
OT  - concurrent chemoradiotherapy
OT  - head and neck cancer
OT  - inflammation
OT  - mortality
OT  - nutrition
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/02/26 06:01
PMCR- 2022/02/06
CRDT- 2022/02/25 01:02
PHST- 2021/12/11 00:00 [received]
PHST- 2022/01/31 00:00 [revised]
PHST- 2022/02/04 00:00 [accepted]
PHST- 2022/02/25 01:02 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/02/26 06:01 [medline]
PHST- 2022/02/06 00:00 [pmc-release]
AID - biomedicines10020388 [pii]
AID - biomedicines-10-00388 [pii]
AID - 10.3390/biomedicines10020388 [doi]
PST - epublish
SO  - Biomedicines. 2022 Feb 6;10(2):388. doi: 10.3390/biomedicines10020388.