PMID- 35206240
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20231209
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 4
DP  - 2022 Feb 12
TI  - Impacts of Neighborhood Characteristics and Surgical Treatment Disparities on 
      Overall Mortality in Stage I Renal Cell Carcinoma Patients.
LID - 10.3390/ijerph19042050 [doi]
LID - 2050
AB  - Racial/ethnic minority groups in the United States have high renal cell carcinoma 
      (RCC) mortality rates. This study assessed surgical treatment disparities across 
      racial/ethnic groups and impacts of neighborhood socioeconomic characteristics on 
      surgical treatments and overall mortality. Stage I RCC patients diagnosed between 
      2004 and 2016 from National Cancer Database were included (n = 238,141). We 
      assessed differences in associations between race/ethnicity and treatment 
      patterns using logistic regression and between race/ethnicity and overall 
      mortality using Cox regression with and without neighborhood characteristics in 
      the regression models. When compared to non-Hispanic Whites (NHWs), American 
      Indians/Alaska Natives and non-Hispanic Blacks (NHBs) were more likely not to 
      receive surgical care and all racial/ethnic minority groups had significantly 
      increased odds of undergoing radical rather than partial nephrectomy, even after 
      adjusting for neighborhood characteristics. Including surgical treatment and 
      neighborhood factors in the models slightly attenuated the association, but NHBs 
      had a significantly increased risk of overall mortality. NHBs who underwent 
      radical nephrectomy had an increased risk of mortality (HR 1.15, 95% CI: 
      1.08-1.23), but not for NHBs who underwent partial nephrectomy (HR 0.92, 95% CI: 
      0.84-1.02). Neighborhood factors were associated with surgical treatment patterns 
      and overall mortality in both NHBs and NHWs. Neighborhood socioeconomic factors 
      may only partly explain RCC disparities.
FAU - Cruz, Alejandro
AU  - Cruz A
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Dickerson, Faith
AU  - Dickerson F
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Pulling, Kathryn R
AU  - Pulling KR
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Garcia, Kyle
AU  - Garcia K
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Gachupin, Francine C
AU  - Gachupin FC
AUID- ORCID: 0000-0003-2349-6486
AD  - Department of Family and Community Medicine, University of Arizona, Tucson, AZ 
      85711, USA.
FAU - Hsu, Chiu-Hsieh
AU  - Hsu CH
AD  - Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ 
      85724, USA.
FAU - Chipollini, Juan
AU  - Chipollini J
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Lee, Benjamin R
AU  - Lee BR
AUID- ORCID: 0000-0001-6558-4551
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
FAU - Batai, Ken
AU  - Batai K
AUID- ORCID: 0000-0002-0317-1118
AD  - Department of Urology, University of Arizona, Tucson, AZ 85724, USA.
LA  - eng
GR  - U54CA143925/CA/NCI NIH HHS/United States
GR  - U54CA143924/CA/NCI NIH HHS/United States
GR  - U54 CA143924/CA/NCI NIH HHS/United States
GR  - 1R21CA248361/CA/NCI NIH HHS/United States
GR  - P30CA023074/CA/NCI NIH HHS/United States
GR  - R21 CA248361/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220212
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - *Carcinoma, Renal Cell/surgery
MH  - Ethnicity
MH  - Health Status Disparities
MH  - Humans
MH  - *Kidney Neoplasms/surgery
MH  - Minority Groups
MH  - Neighborhood Characteristics
MH  - United States/epidemiology
PMC - PMC8872003
OTO - NOTNLM
OT  - cancer health disparities
OT  - geospatial
OT  - kidney cancer
OT  - neighborhood socioeconomic status
OT  - surgical disparities
COIS- The authors do not have conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/03/22 06:00
PMCR- 2022/02/12
CRDT- 2022/02/25 01:08
PHST- 2021/11/30 00:00 [received]
PHST- 2022/01/15 00:00 [revised]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/02/25 01:08 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
PHST- 2022/02/12 00:00 [pmc-release]
AID - ijerph19042050 [pii]
AID - ijerph-19-02050 [pii]
AID - 10.3390/ijerph19042050 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Feb 12;19(4):2050. doi: 
      10.3390/ijerph19042050.