PMID- 35206262
OWN - NLM
STAT- MEDLINE
DCOM- 20220321
LR  - 20220321
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 4
DP  - 2022 Feb 12
TI  - Can Exposure to Environmental Pollutants Be Associated with Less Effective 
      Chemotherapy in Cancer Patients?
LID - 10.3390/ijerph19042064 [doi]
LID - 2064
AB  - Since environmental pollutants are ubiquitous and many of them are resistant to 
      degradation, we are exposed to many of them on a daily basis. Notably, these 
      pollutants can have harmful effects on our health and be linked to the 
      development of disease. Epidemiological evidence together with a better 
      understanding of the mechanisms that link toxic substances with the development 
      of diseases, suggest that exposure to some environmental pollutants can lead to 
      an increased risk of developing cancer. Furthermore, several studies have raised 
      the role of low-dose exposure to environmental pollutants in cancer progression. 
      However, little is known about how these compounds influence the treatments given 
      to cancer patients. In this work, we present a series of evidences suggesting 
      that environmental pollutants such as bisphenol A (BPA), benzo[a]pyrene (BaP), 
      persistent organic pollutants (POPs), aluminum chloride (AlCl(3)), and airborne 
      particulate matter may reduce the efficacy of some common chemotherapeutic drugs 
      used in different types of cancer. We discuss the potential underlying molecular 
      mechanisms that lead to the generation of this chemoresistance, such as apoptosis 
      evasion, DNA damage repair, activation of pro-cancer signaling pathways, drug 
      efflux and action of antioxidant enzymes, among others.
FAU - Lagunas-Rangel, Francisco Alejandro
AU  - Lagunas-Rangel FA
AUID- ORCID: 0000-0001-7730-6452
AD  - Department of Surgical Sciences, Functional Pharmacology and Neuroscience, 
      Uppsala University, BMC Box 593, Husargatan 3, 75124 Uppsala, Sweden.
FAU - Liu, Wen
AU  - Liu W
AD  - Department of Surgical Sciences, Functional Pharmacology and Neuroscience, 
      Uppsala University, BMC Box 593, Husargatan 3, 75124 Uppsala, Sweden.
FAU - Schioth, Helgi B
AU  - Schioth HB
AD  - Department of Surgical Sciences, Functional Pharmacology and Neuroscience, 
      Uppsala University, BMC Box 593, Husargatan 3, 75124 Uppsala, Sweden.
AD  - Institute of Translational Medicine and Biotechnology, I. M. Sechenov First 
      Moscow State Medical University, 8-2 Trubetskaya Str. Moscow, 119991 Moscow, 
      Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220212
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Environmental Pollutants)
RN  - 0 (Particulate Matter)
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Benzo(a)pyrene/toxicity
MH  - Environmental Exposure
MH  - *Environmental Pollutants/toxicity
MH  - Humans
MH  - *Neoplasms/chemically induced/drug therapy/epidemiology
MH  - Particulate Matter
PMC - PMC8871977
OTO - NOTNLM
OT  - PI3K/AKT pathway
OT  - antioxidant enzymes
OT  - apoptosis
OT  - chemotherapy resistance
OT  - drug efflux
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/03/22 06:00
PMCR- 2022/02/12
CRDT- 2022/02/25 01:08
PHST- 2022/01/19 00:00 [received]
PHST- 2022/02/07 00:00 [revised]
PHST- 2022/02/09 00:00 [accepted]
PHST- 2022/02/25 01:08 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/03/22 06:00 [medline]
PHST- 2022/02/12 00:00 [pmc-release]
AID - ijerph19042064 [pii]
AID - ijerph-19-02064 [pii]
AID - 10.3390/ijerph19042064 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Feb 12;19(4):2064. doi: 
      10.3390/ijerph19042064.