PMID- 35211094
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220531
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Dissecting the Association of Apolipoprotein E Gene Polymorphisms With Type 2 
      Diabetes Mellitus and Coronary Artery Disease.
PG  - 838547
LID - 10.3389/fendo.2022.838547 [doi]
LID - 838547
AB  - BACKGROUND: Apolipoprotein E (APOE) gene mediates lipoprotein clearance and is 
      one of the most studied candidate genes for type 2 diabetes mellitus (T2DM) and 
      coronary artery disease (CAD). This study was performed to determine the 
      association between APOE polymorphisms and T2DM with and without CAD, and its 
      effect on plasma lipid levels in a Chinese population. METHODS: A total of 1,414 
      subjects involving 869 patients and 545 health individuals were recruited. These 
      patients were categorized into three distinct groups: 264 in T2DM group, 401 in 
      CAD group, and 204 in T2DM+CAD group. Logistic regression analysis was used to 
      obtain odds ratio (OR) and 95% confidence interval (CI) in predicting the risk 
      probability of APOE. Besides, a meta-analysis was preformed to integrate an 
      evaluation index to evaluate their associations. RESULTS: Genotype frequency 
      ratio of genotype ϵ3/4 and allele ϵ4 among the CAD patients with or without T2DM 
      was obviously increased. Compared with ϵ3/3 genotype, the ϵ3/4 genotype had a 
      significant increased risk of CAD (adjusted OR = 1.90, 95% CI = 1.30-2.77) and 
      T2DM+CAD (adjusted OR = 1.95, 95% CI = 1.24-3.08). In the meta-analysis, four 
      studies were included and provided a strong evidence for the APOE ϵ4 mutation 
      elevating the risk of CAD in patients with T2DM (ϵ3/ϵ4+ϵ4/ϵ4 vs. ϵ3/ϵ3, OR = 
      1.51, 95% CI = 1.13-2.02). In the T2DM group, the plasma levels of low-density 
      lipoprotein cholesterol (LDL-C) showed significant difference among the three 
      APOE isoforms. The high-density lipoprotein cholesterol (HDL-C) levels of CAD 
      patients with ϵ4-bearing genotypes were lower than those with ϵ3/3 genotype. 
      CONCLUSIONS: Our results indicate that APOE gene polymorphisms are related to CAD 
      with or without T2DM and have influence on lipid profiles in both T2DM and CAD 
      patients.
CI  - Copyright (c) 2022 Wu, Zhang, Zhao, Rong, Huang, Wang and Xu.
FAU - Wu, Lei
AU  - Wu L
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Zhao, Hong
AU  - Zhao H
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Rong, Guodong
AU  - Rong G
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Huang, Peijun
AU  - Huang P
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
FAU - Xu, Ting
AU  - Xu T
AD  - Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - National Key Clinical Department of Laboratory Medicine, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220208
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - *Apolipoproteins E/genetics
MH  - *Coronary Artery Disease
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Genetic
PMC - PMC8861372
OTO - NOTNLM
OT  - apolipoprotein E
OT  - coronary artery disease
OT  - meta-analysis
OT  - polymorphism
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/04/01 06:00
PMCR- 2022/01/01
CRDT- 2022/02/25 05:37
PHST- 2021/12/17 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/02/25 05:37 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.838547 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Feb 8;13:838547. doi: 
      10.3389/fendo.2022.838547. eCollection 2022.