PMID- 35211590
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220226
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 5
DP  - 2022 Feb 16
TI  - Significance of serum glucagon-like peptide-1 and matrix Gla protein levels in 
      patients with diabetes and osteoporosis.
PG  - 1527-1535
LID - 10.12998/wjcc.v10.i5.1527 [doi]
AB  - BACKGROUND: Osteoporosis is a systemic bone disease characterized by decreased 
      bone mass, impaired bone mass, and reduced bone strength that leads to increased 
      bone fragility and fracture. Type 2 diabetes mellitus (T2DM) complicated with 
      osteoporosis is a common systemic metabolic bone disease, and reduced bone mass 
      and bone strength are considered the main clinical features; however, the 
      pathogenesis of this disease has not been fully clarified. Its occurrence is 
      considered related to sex, age, and genetic factors. There are many risk factors 
      for diabetes complicated with osteoporosis. Therefore, exploring these risk 
      factors will help prevent it. AIM: To investigate the relationships among serum 
      glucagon-like peptide-1 (GLP-1) levels, matrix Gla protein (MGP) levels, and 
      diabetes with osteoporosis. METHODS: Sixty patients with T2DM complicated with 
      osteoporosis confirmed by the endocrinology department of our hospital were 
      selected as the case group. Sixty T2DM patients with bone loss were selected as 
      the control group. Sixty healthy participants were selected as the healthy group. 
      The general data, bone mineral density index, and bone metabolic markers of the 
      three groups were compared. The relationships among GLP-1 levels, MGP levels, and 
      the bone mineral density index of the case group were analyzed using linear 
      correlation analysis and a logistic regression model. RESULTS: Differences in 
      sex, smoking, and drinking among the case group, control group, and healthy group 
      were not statistically significant (P > 0.05). The mean age of the case group was 
      older than those of the control and healthy groups (P < 0.05). The body mass 
      index, fasting plasma glucose level, HbA1c level, hypertension rate, and coronary 
      heart disease rate of the case and control groups were higher than those of the 
      healthy group (P < 0.05). The serum GLP-1 and MGP levels of the case group were 
      lower than those of the control and healthy groups; these differences were 
      statistically significant (P < 0.05). The serum GLP-1 and MGP levels of the 
      control group were lower than those of the healthy group; these differences were 
      statistically significant (P < 0.05). The serum GLP-1 and MGP levels of the case 
      group were significantly positively correlated with the bone mineral density 
      values of the hip and lumbar spine (P < 0.05). The results of the logistic 
      regression model showed that age and duration of diabetes were independent risk 
      factors for osteoporosis in diabetic patients (P < 0.05) and that increased GLP-1 
      and MGP values were protective factors against osteoporosis in diabetic patients 
      (P < 0.05). CONCLUSION: Serum GLP-1 and MGP levels of diabetic patients with 
      osteoporosis were significantly decreased and positively correlated with bone 
      mineral density and were independent risk factors for osteoporosis in diabetic 
      patients.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xie, Fei-Fei
AU  - Xie FF
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Zhang, Yu-Fang
AU  - Zhang YF
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Hu, Yan-Fang
AU  - Hu YF
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Xie, Yun-Yun
AU  - Xie YY
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Wang, Xiao-Ying
AU  - Wang XY
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Wang, Shu-Zhen
AU  - Wang SZ
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China.
FAU - Xie, Bao-Qiang
AU  - Xie BQ
AD  - Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou 
      Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China. 
      xiebaoqiang1629@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8855254
OTO - NOTNLM
OT  - Bone mineral density
OT  - Diabetes mellitus
OT  - Glucagon-like peptide-1
OT  - Matrix Gla protein
OT  - Osteoporosis
OT  - Systemic bone disease
COIS- Conflict-of-interest statement: No conflict of interest.
EDAT- 2022/02/26 06:00
MHDA- 2022/02/26 06:01
PMCR- 2022/02/16
CRDT- 2022/02/25 05:39
PHST- 2021/11/14 00:00 [received]
PHST- 2021/12/27 00:00 [revised]
PHST- 2022/01/11 00:00 [accepted]
PHST- 2022/02/25 05:39 [entrez]
PHST- 2022/02/26 06:00 [pubmed]
PHST- 2022/02/26 06:01 [medline]
PHST- 2022/02/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i5.1527 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 Feb 16;10(5):1527-1535. doi: 10.12998/wjcc.v10.i5.1527.